异种肾移植临床前研究进展及未来潜在受者选择  

Recent advances in preclinical research of renal xenotransplantation and selection of potential recipients in the future

作　　者：涂宇豪 冯豪 朱兰[1] 陈刚[1] Tu Yuhao;Feng Hao;Zhu Lan;Chen Gang(Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Key Laboratory of Organ Transplantation,Ministry of Education,NHC Key Laboratory of Organ Transplantation,Key Laboratory of Organ Transplantation,Chinese Academy of Medical Sciences,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院器官移植研究所器官移植教育部重点实验室国家卫生健康委员会器官移植重点实验室、中国医学科学院器官移植重点实验室,武汉430030

出　　处：《中华器官移植杂志》2023年第2期122-128,共7页Chinese Journal of Organ Transplantation

摘　　要：肾移植在历代移植人的努力下迅猛发展,如今已成为治疗终末期肾病的最佳手段,但肾脏的供需不平衡一直制约着肾移植的开展。在这种困境下,异种移植成为解决器官供需不平衡的这一严重问题的最佳替代方案之一。本文结合近几年异种肾移植文献报道和近期的猪到人肾移植和心脏移植案例对异种肾移植进行回顾总结并展望其未来的临床转化应用。After continuous efforts from generations of transplant surgeons,kidney transplantation(KT)has become an optimal treatment for end-stage renal disease.However,an imbalance between supply and demand of organs has always restricted the development of KT.For this clinical dilemma,xenotransplantation is expected to become one practical alternative for alleviating organ shortage.This review summarized recent literature reports of kidney xenotransplantation and the latest cases of pig-to-human kidney and heart transplantations.Also clinical transformations and applications of kidney xenotransplantation were discussed.

关 键 词：肾移植 异种移植 免疫排斥 基因编辑 免疫抑制 

分 类 号：R699.2[医药卫生—泌尿科学]