调经消脂汤联合耳穴埋针治疗肥胖型多囊卵巢综合征40例疗效观察  

Therapeutic effects of Tiaojing Xiaozhi Decoction combined with auricular acupoint embedding acupuncture on polycystic ovary syndrome in 40 obese cases

作　　者：王世帅 常淑华 张蔚苓 Wang Shishuai;Chang Shuhua;Zhang Weiling(Department of Gynecology,Ningbo Municipal Hospital of Traditional Chinese Medicine,Ningbo 315010,Zhejiang Province,China)

机构地区：[1]宁波市中医院妇科,宁波315010

出　　处：《中国基层医药》2023年第3期405-410,共6页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨调经消脂汤联合耳穴埋针治疗肥胖型多囊卵巢综合征的疗效。方法选取宁波市中医院2020年7月至2021年6月治疗的肥胖型多囊卵巢综合征(脾肾两虚证)患者120例,采用随机数字表法分为中药组、耳针组、针药组各40例。中药组口服调经消脂汤治疗,耳针组采用耳穴埋针治疗,针药组采用调经消脂汤联合耳穴埋针治疗。观察三组治疗前后中医证候积分、体质量指数、腰围、臀围、腰臀比、睾酮、黄体生成素、卵泡刺激素、黄体生成素/卵泡刺激素、雌二醇、泌乳素、重组人瘦素、脂联素和肿瘤坏死因子α、白细胞介素6的变化及临床疗效。结果针药组总有效率(87.5%)高于中药组(77.5%)、耳针组(80.0%),但三组差异无统计学意义(P>0.05)。治疗后,针药组中医证候积分为(10.40±2.38)分,低于中药组的(12.35±3.32)分、耳针组的(14.18±3.51)分(F=14.78,P<0.05);针药组体质量指数、腰围、臀围、腰臀比均优于中药组、耳针组(F=4.11、18.59、3.62、13.33,均P<0.05);针药组黄体生成素、黄体生成素/卵泡刺激素均优于中药组、耳针组(均P<0.05);针药组、中药组重组人瘦素、脂联素均较治疗前改善(均P<0.05),耳针组仅脂联素较治疗前改善(P<0.05);针药组肿瘤坏死因子α[(4.12±1.54)μg/L]及白细胞介素6[(3.09±1.41)ng/L]均明显低于治疗前(t=21.66、10.42,均P<0.05)。结论调经消脂汤联合耳穴埋针治疗肥胖型多囊卵巢综合征,可降低体质量指数、脂肪因子和炎性因子水平,有助于改善性激素水平和中医证候积分,具有明显的疗效。Objective To investigate the therapeutic effects of Tiaojing Xiaozhi Decoction combined with auricular acupoint embedding acupuncture on polycystic ovary syndrome in obese patients.Methods A total of 120 obese cases of polycystic ovary syndrome(spleen and kidney deficiency syndrome)treated in Ningbo Municipal Hospital of Traditional Chinese Medicine from July 2020 to June 2021 were included in this study.They were randomly assigned to undergo treatment with either Tiaojing Xiaozhi Decoction(Chinese medicine group,n=40),auricular acupoint embedding acupuncture(ear acupuncture group,n=40),or Tiaojing Xiaozhi Decoction and auricular acupoint embedding acupuncture(combined therapy group,n=40).Traditional Chinese medicine(TCM)syndrome integral,body mass index,waist circumference,hip circumference,waist-to-hip ratio,testosterone,luteinizing hormone,follicle-stimulating hormone,luteinizing hormone/follicle-stimulating hormone,estradiol,prolactin,recombinant human leptin,adiponectin,tumor necrosis factorα,interleukin-6,and clinical efficacy were compared among groups before and after treatment.Results Total response rate in the combined therapy group was 87.5%,which was slightly but not significantly,higher than 77.5%in the Chinese medicine group and 80.0%in the ear acupuncture group,and there was no significant difference in total response rate among the three groups(all P>0.05).After treatment,TCM syndrome integral in the combined therapy was(10.40±2.38)points,which was significantly lower than(12.35±3.32)points in the Chinese medicine group and(14.18±3.51)points in the ear acupuncture group(F=14.78,P<0.05).The body mass index,waist circumference,hip circumference,and waist-to-hip ratio in the combined therapy group were superior to those in the Chinese medicine and ear acupuncture groups(F=4.11,18.59,3.62,13.33,all P<0.05).Luteinizing hormone and luteinizing hormone/follicle-stimulating hormone in the combined therapy group were superior to those in the Chinese medicine and ear acupuncture groups(all P<0.05).After

关 键 词：多囊卵巢综合征 肥胖症 病态 调经消脂汤 耳穴疗法 证候积分 人体质量指数 脂肪因子类 性激素 肿瘤坏死因子α 白细胞介素6 

分 类 号：R271.9[医药卫生—中西医结合]