宣白承气汤辅助治疗急性呼吸窘迫综合征临床观察  

Clinical observation of Xuanbai Chengqi Decoction in adjuvant treatment of acute respiratory distress syndrome

作　　者：鲁玉瑶 郑爱华[2] LU Yuyao;ZHENG Aihua(Graduate School,Hunan University of Chinese Medicine,Hunan,Changsha 410000,China;Department of Critical Care Medicine,the Second Hospital of Hunan University of Chinese Medicine,Hunan,Changsha 410000,China)

机构地区：[1]湖南中医药大学研究生院,湖南长沙410000 [2]湖南中医药大学第二附属医院重症医学科,湖南长沙410000

出　　处：《中国医药科学》2023年第7期11-15,共5页China Medicine And Pharmacy

基　　金：湖南省中医药科研计划项目(D2022011)。

摘　　要：目的观察宣白承气汤辅助治疗急性呼吸窘迫综合征(ARDS)的临床效果。方法选择2022年1—6月湖南省中医药大学第二附属医院危重症医学科住院治疗的ARDS患者60例,观察组与对照组(随机数表法)各30例。两组均予以西医常规治疗方法,观察组加用宣白承气汤,中药汤剂予以口服或鼻饲。两组均治疗7 d后观察比较炎症因子水平[白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血清降钙素原(PCT)、C反应蛋白(CRP)]、血气分析相关指标[氧分压(PO_(2))、二氧化碳分压(PCO_(2))、氧合指数(PaO_(2)/FiO_(2))、酸碱度(pH)]、急性生理与慢性健康Ⅱ(APACHEⅡ)评分、序贯器官衰竭评分(SOFA)、ICU住院天数、呼吸机辅助通气时间。结果观察组加用宣白承气汤后,炎症因子水平显著低于对照组,差异有统计学意义(P<0.05);观察组治疗后PO_(2)、PCO_(2)、PaO_(2)/FiO_(2)水平显著优于对照组,差异有统计学意义(P<0.05);观察组治疗后APACHEⅡ评分和SOFA评分显著低于对照组,差异有统计学意义(P<0.05);ICU住院时间和呼吸机辅助通气时间也显著短于对照组,差异有统计学意义(P<0.05)。结论宣白承气汤辅助治疗ARDS后疗效显著、有较好的临床效果。Objective To observe the clinical efficacy of Xuanbai Chengqi Decoction in adjuvant treatment of acute respiratory distress syndrome(ARDS).Methods A total of 60 ARDS patients hospitalized in the Department of Critical Care Medicine of the Second Hospital of Hunan University of Chinese Medicine from January to June,2022 were selected,and they were divided into the observation group(n=30)and the control group(n=30)(according to the random number table method).Both groups were treated with conventional western medication method.And the observation group was additionally treated with Xuanbai Chengqi Decoction,and the Chinese materia medica decoction was taken by oral administration or nasal feeding.After 7 days of treatment,the levels of inflammatory factors(interleukin-6[IL-6],tumor necrosis factor-α[TNF-α],serum procalcitonin[PCT]and C-reactive protein[CRP]),blood gas analysis related indices(partial pressure of oxygen[PO_(2)],partial pressure of carbon dioxide[PCO_(2)],oxygenation index[PaO_(2)/FiO_(2)]and potential of hydrogen[pH]),acute physiology and chronic health evaluationⅡ(APACHEⅡ)score,sequential organ failure assessment(SOFA)score,days in intensive care unit(ICU),and ventilator-assisted ventilation time in both groups were observed and compared.Results After treatment,all levels of inflammatory factors in the observation group were obviously lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of PO_(2),PCO_(2)and PaO_(2)/FiO_(2)in the observation group were obviously superior to those in the control group,with statistically significant differences(P<0.05).After treatment,APACHEⅡscore and SOFA score in the observation group were obviously lower than those in the control group,with statistically significant differences(P<0.05).The ICU hospitalization time and ventilator-assisted ventilation time in the observation group were also obviously shorter than those in the control group,with statistically significant differences(P<0.05).Conclus

关 键 词：宣白承气汤 急性呼吸窘迫综合征 血气分析 机械通气时间 

分 类 号：R259[医药卫生—中西医结合]