糖尿病肾病患者自身抗体检测结果的特点分析  

Characteristics of autoantibody test results in patients with diabetic nephropathy

作　　者：李清元[1] LI Qingyuan(Department of Clinical Laboratory,Jilin Central General Hospital,Jilin,Jilin 132013,China)

机构地区：[1]吉林省吉林市中心医院检验科,吉林吉林132013

出　　处：《中国医药科学》2023年第7期167-169,181,共4页China Medicine And Pharmacy

摘　　要：目的探讨糖尿病肾病患者自身抗体检测结果的特点。方法选择2021年9月至2022年8月在吉林市中心医院(我院)治疗的糖尿病肾病患者77例为治疗对象,将其纳入糖尿病肾病组。选择同期在我院治疗的糖尿病患者80例为对照,将其纳入糖尿病组。比较两组患者抗心磷脂抗体(ACLA)、抗中性粒细胞胞浆抗体(ANCA)和抗肾小球基底膜抗体(GBMA)检测结果。另以糖尿病肾病患者为对象,从患者年龄、病程和Mogensen分期的角度,分析自身抗体检测结果的差异。结果糖尿病肾病组患者ACLA和GBMA抗体阳性率均大于糖尿病组患者,差异有统计学意义(P<0.05)。不同年龄糖尿病肾病患者ACLA、ANCA、GBMA阳性率比较,差异无统计学意义(P>0.05);病程>5年和Ⅱ期的糖尿病肾病患者ACLA和GBMA抗体阳性率分别大于病程1~5年和Ⅰ期的糖尿病肾病患者,差异有统计学意义(P<0.05)。结论糖尿病肾病患者因病程和Mogensen分期的不同,部分自身抗体检测指标具有差异,其在一定程度上,可作为判定患者病程进展的参考。Objective To explore the characteristics of autoantibody test results in patients with diabetic nephropathy.Methods A total of 77 patients with diabetic nephropathy treated in Jilin Central General Hospital from September 2021 to August 2022 were selected as subjects and included in a diabetic nephropathy group,and another 80 diabetic patients treated at the hospital during the same period were selected as controls and included in a diabetic group.The test results of anti-cardiolipin antibody(ACLA),anti-neutrophil cytoplasmic antibody(ANCA)and glomerular basement membrane antibody(GBMA)were compared between the two groups.In addition,the differences in autoantibody test results among patients with diabetic nephropathy of different ages,disease durations and Mogensen stages were analyzed.Results The positive rates of ACLA and GBMA in the diabetic nephropathy group were higher than those in the diabetic group,with differences were statistically significant(P<0.05).There was no significant difference in the positive rates of ACLA,ANCA and GBMA diabetes nephropathy patients of different ages(P>0.05);the positive rates of ACLA and GBMA in diabetes nephropathy patients with a course of more than 5 years and stageⅡwere significantly higher than those in diabetes nephropathy patients with a course of 1-5 years and stageⅠ,respectively,with differences were statistically significant(P<0.05).Conclusion Some autoantibody test indexes in patients with diabetic nephropathy may vary depending on the disease duration and Mogensen stage,which can be used as a reference to determine the progression of diseases to a certain extent.

关 键 词：糖尿病 糖尿病肾病 自身抗体 检验医学 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]