老年患者血清尿酸与肌钙蛋白T水平的关系  

Association between Serum Levels of Uric Acid and Troponin T in the Elderly Patients

作　　者：赵辰荷 ZHAO Chenhe(Health Care Ward,Zhongshan Hospital Affiliated to Xiamen University,Xiamen 361004,China)

机构地区：[1]厦门大学附属中山医院保健病房,福建厦门361004

出　　处：《中国医药指南》2023年第10期54-57,共4页Guide of China Medicine

摘　　要：目的本研究旨在分析老年患者血清尿酸与肌钙蛋白T水平的关系。方法本研究是以医院为中心的回顾性横断面研究,纳入了100例老年患者,对其进行基本信息收集和血清生化指标测定。本研究采用广义相加模型进行平滑曲线拟合,采用对数似然比检验进行阈值效应和饱和效应分析,从而分析老年患者血清尿酸与肌钙蛋白T水平的关系。双侧的P<0.05认为有统计学意义。结果在未校正模型及各校正模型下,当血清尿酸水平<360μmol/L时,其水平与血清肌钙蛋白T水平呈负相关;而当血清尿酸水平≥360μmol/L时,其水平与血清肌钙蛋白T水平呈正相关。其中模型3校正了一系列混杂因素(包括年龄、性别、吸烟史、饮酒史、糖尿病史、高血压病史、肾脏病史、空腹血糖、三酰甘油、低密度脂蛋白及肌酐水平),当血清尿酸水平<360μmol/L时,其水平与血清肌钙蛋白T水平呈显著负相关(β=-0.14,95%CI=-0.21~-0.06,P<0.01);而血清尿酸水平≥360μmol/L时,其水平与血清肌钙蛋白T水平呈显著正相关(β=0.12,95%CI=0.01~0.23,P=0.04)。结论老年患者血清尿酸水平<360μmol/L时,与血清肌钙蛋白T水平呈负相关;当血清尿酸水平≥360μmol/L时,与血清肌钙蛋白T水平呈正相关。在临床实践中为降低老年患者急性心血管事件的发生风险,需将血尿酸水平控制在合适范围。Objective This study analyzed the relationship between serum levels of uric acid and troponin T in the elderly patients.Methods In this hospital-centered retrospective cross-sectional study,100 elderly patients were enrolled,and their basic information and serum biochemical indexes were collected.In order to clarify the association between uric acid and troponin T in the elderly patients,we used generalized additive models to make smooth curve fitting and used a log likelihood test to analyze threshold and saturation effect.A two-sided P<0.05 was considered statistically significant.Results In unadjusted models and multiple adjusted models,when serum levels of uric acid was less than 360μmol/L,it correlated negatively with troponin T levels;when serum levels of uric acid was more than 360μmol/L,it was related to enhanced levels of troponin T.In multiple adjusted model 3,after adjusted for several factors(including age,gender,smoking history,drinking history,history of diabetes mellitus,history of hypertension,history of kidney disease,fasting glucose,triglyceride,low-density lipoprotein,and creatinine),when serum levels of uric acid was less than 360μmol/L,it was negatively and significantly related to troponin T levels(β=-0.14,95%CI=-0.21--0.06,P<0.01);while when serum levels of uric acid was more than 360μmol/L,it correlated with higher troponin T levels significantly(β=0.12,95%CI=0.01-0.23,P=0.04).Conclusion In the elderly patients,when serum levels of uric acid was less than 360μmol/L,it was associated with troponin T levels negatively;when serum levels of uric acid was more than 360μmol/L,it was associated with troponin T levels positively.So in clinical practice,in order to reduce the risk of acute cardiovascular events in the elderly patients,serum uric acid levels should be controlled within an appropriate range.

关 键 词：老年患者 尿酸 肌钙蛋白T 

分 类 号：R589.7[医药卫生—内分泌]