平喘固本汤加减联合硫酸沙丁胺醇气雾剂吸入治疗老年慢性持续期哮喘的临床研究  

Clinical Study of Pingchuan Guben Decoction Combined with Salbutamol Sulfate Aerosol Inhalation in the Treatment of Chronic Persistent Asthma in the Elderly

作　　者：李晓菁 LI Xiaojing(Department of Medicine,Zhangping Hospital of Traditional Chinese Medicine,Zhangping 364400,China)

机构地区：[1]漳平市中医院内科,福建漳平364400

出　　处：《中国医药指南》2023年第10期116-118,共3页Guide of China Medicine

摘　　要：目的探讨平喘固本汤加减联合硫酸沙丁胺醇气雾剂吸入治疗老年慢性持续期哮喘的临床疗效。方法选择2020年1月至2022年6月来本院就诊的70例老年慢性持续期哮喘患者作为研究对象,根据患者就诊顺序将患者随机分为对照组35例和观察组35例,对照组患者单纯给予硫酸沙丁胺醇气雾剂吸入治疗,2掀(200μg)/次,每日4次,观察组患者在对照组的基础上再口服平喘固本汤加减,每日1剂,早晚分服,两组均治疗90 d,治疗90 d结束时参照《中药新药临床研究指导原则》评价两组临床疗效,治疗前、治疗90 d结束时进行哮喘控制测试(ACT)评分,比较妨碍日常活动、呼吸困难、夜间憋醒、急救药使用、哮喘控制情况评分,治疗前、治疗90 d结束时采用肺功能检查仪测定两组患者用力肺活量(FVC)、第1秒用力呼吸容积(FEV1)、最大呼气流速(PEF),观察两组患者治疗过程不良反应发生情况。结果观察组治疗90 d结束时的临床总有效率、妨碍日常活动、呼吸困难、夜间憋醒、急救药使用、哮喘控制评分、FVC、FEV1、PEF均明显高于对照组,P<0.05。两组患者治疗过程中未见明显不良反应。结论在硫酸沙丁胺醇气雾剂吸入治疗的基础上再给予平喘固本汤加减治疗能够优化现有治疗方案,提高临床治疗效果。Objective To investigate the clinical effect of pingchuan guben decoction combined with salbutamol sulfate aerosol inhalation in the treatment of senile chronic asthma.Methods A total of 70 elderly patients with chronic persistent asthma who came to our hospital from January 2020 to June 2022 were selected as the study objects.According to the order of treatment,the patients were randomly divided into the control group(35 cases)and the observation group(35 cases).The patients in the control group were simply treated with salbutamol sulfate aerosol inhalation,2 times(200μg)/time,4 times a day.Observation group was additionally given pingchuan guben decoction on the basis of control group,one dose each day,divided into morning and evening.Both groups were treated for 90 days.At the end of 90 days of treatment,the clinical efficacy of the two groups was evaluated according to the Guidelines for Clinical Research on New Chinese Medicines.The scores of obstructing daily activities,dyspnea,waking up at night,emergency treatment and asthma control were compared.Forced vital capacity(FVC),forced breathing volume at the first second(FEV1)and maximum expiratory flow rate(PEF)of the two groups were measured by pulmonary function test instrument before treatment and at the end of 90 days of treatment,and the occurrence of adverse reactions during treatment was observed in the two groups.Results At the end of 90 days treatment,the total clinical effective rate,the scores of obstruction of daily activities,dyspnea,awakening at night,emergency treatment and asthma control,FVC,FEV1 and PEF in the observation group were significantly higher than those in the control group(P<0.05).No obvious adverse reactions were observed in the two groups during treatment.Conclusion On the basis of inhaling salbutamol sulfate aerosol,the treatment of pingchuan guben decoction can optimize the existing treatment plan and improve the clinical therapeutic effect.

关 键 词：老年慢性持续期哮喘 平喘固本汤加减 硫酸沙丁胺醇气雾剂 疗效 

分 类 号：R562.25[医药卫生—呼吸系统]