Solvent-mediated handedness inversed and amplified circularly polarized luminescence system based on camptothecin derivative  

作　　者：Xuan Wu Ming Liu Cheng Zheng Yingying Wang Yujing Zheng Yuna Qian Zhiyong Liao Guoyong Fang Jianliang Shen 

机构地区：[1]Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325000,China [2]School of Ophthalmology and Optometry,School of Biomedical Engineering,Wenzhou Medical University,Wenzhou 325035,China [3]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou 325001,China [4]College of Life and Environmental Science,Wenzhou University,Wenzhou 325000,China [5]College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou 325000,China [6]National Laboratory of Solid State Microstructures,Nanjing University,Nanjing 210093,China

出　　处：《Chinese Chemical Letters》2023年第2期188-192,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (No. 22101280);Wenzhou Medical University (No. KYYW201901);University of Chinese Academy of Science (Nos. WIBEZD201700103 and WIUCASQD2020005);Zhejiang Provincial Natural Science Foundation (No. LQ20B020009) for financial support。

摘　　要：To realize the handedness controllable circularly polarized luminescence(CPL) system remains challenging. Herein, the solvent-mediated CPL inversion and amplification systems were successfully constructed by camptothecin derivative(CPT-A). Due to the planar structure of N,N-dimethylformamide, it could coassemble with CPT-A, resulting in the alteration of g_(lum) from –0.0082 to +0.0085 by increasing water content. While in the non-planar solvent(hexafluoroisopropanol), the g_(lum) was amplified to 0.034 with the increase in water content. Moreover, the CPT-A could react with the glutathione, resulting in the anticancer drug CPT to make it more toxic to the cancer cells. Overall, the handedness controllable CPL systems were realized by tuning the supramolecular self-assembly of a prodrug.

关 键 词：Circularly polarized luminescence Chirality inversion and amplification Solvent-incorporated self-assembly Camptothecin derivative Stimuli-responsiveness 

分 类 号：TB34[一般工业技术—材料科学与工程]