康妇炎胶囊对支原体属感染慢性盆腔炎血清炎症因子及盆腔血流动力学的影响  

Effects of Kangfuyan Capsule(康妇炎胶囊)on Serum Inflammatory Factors and Pelvic Hemodynamics in Patients with Chronic Pelvic Inflammatory Disease Caused by Mycoplasma

作　　者：顾海娜 谢琼艳 李书艳 谢艺溶 GU Haina;XIE Qiongyan;LI Shuyan;XIE Yirong(Zhoushan Women's and Children's Hospital,Zhoushan 316000,Zhejiang,China)

机构地区：[1]舟山市妇女儿童医院,浙江舟山316000

出　　处：《中华中医药学刊》2023年第2期201-204,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省医药卫生科技计划项目(2020KY1001)。

摘　　要：目的探讨康妇炎胶囊对支原体属感染慢性盆腔炎患者血清炎症因子及盆腔血流动力学的影响。方法将100例支原体属感染慢性盆腔炎患者随机分两组,每组50例,对照组治疗药物给予阿奇霉素片,观察组给予康妇炎胶囊联合阿奇霉素片,4周后停药,观察中医证候积分和血清炎症因子、盆腔卵巢和子宫动脉血流动力学变化。结果中医证候积分:治疗前无统计学意义(P>0.05),治疗后积分降低(P<0.05),且观察组更低(P<0.05);血清白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、C反应蛋白(CRP):治疗前无统计学意义(P>0.05),IL-2和IL-4治疗后升高(P<0.05),且观察组更高(P<0.05),TNF-α和CRP治疗后降低(P<0.05),且观察组更低(P<0.05);卵巢动脉及子宫动脉搏动指数(PI)、阻力指数(RI)、收缩期峰值流速(PSV):治疗前无统计学意义(P>0.05),PI及PSV治疗后升高(P<0.05),且观察组更高(P<0.05),RI降低(P<0.05),且观察组更低(P<0.05);停药3个月、6个月时;复发率对照组20.00%(10/50)、32.00%(16/50),观察组4.00%%(2/50)、12.00%(6/50),有统计学意义(P<0.05);治疗总有效率观察组96.00%(48/50),对照组82.00%(41/50),有统计学意义(P<0.05)。结论康妇炎胶囊治疗支原体属感染慢性盆腔炎对改善临床症状有促进作用,利于炎症的控制,有助于改善盆腔血流循环,降低复发率,提高治疗疗效。Objective To discuss the effects of Kangfuyan Capsule(康妇炎胶囊)on serum inflammatory factors and pelvic hemodynamics in patients with chronic pelvic inflammatory disease caused by mycoplasma.Methods We collected 80 cases of pa⁃tients with chronic pelvic inflammatory disease caused by mycoplasma were randomly divided into control group(40 cases)and observation group(40 cases).The control group was treated with oral azithromycin and the observation group received Kangfuyan Capsule combined with oral azithromycin.The duration of medication was 4 weeks.TCM syndrome scores and serum inflammato⁃ry factors and pelvic hemodynamics were observed.Results The scores of TCM syndromes:there was no significant difference be⁃fore treatment(P>0.05),and after treatment the scores were decreased compared(P<0.05).The scores of the observation group were very low(P<0.05).Serum levels of interleukin-2(IL-2),interleukin-4(IL-4),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP):There was no significant difference before treatment(P>0.05).The levels of IL-2 and IL-4 were higher after treatment(P<0.05)and the levels of the observation group were very high(P<0.05).The levels of TNF-αand CRP were decreased(P<0.05)and the levels of the observation group were very low(P<0.05).The ovarian artery and puterine artery pulsatile index(PI),resistance index(RI)and peak systolic flow rate(PSV):There was no significant difference before treatment(P>0.05).PI and PSV were higher after treatment(P<0.05)and those of the observation group were were very high(P<0.05).RI was decreased after treatment(P<0.05)and that of the observation group was very low(P<0.05).The control group’s recurrence rates were 20.00%(10/50)and 32.00%(16/50)at 3 and 6 months,and the total effective rate was 96.00%(48/50).The observation group’s recurrence rates were 4.00%(21/50)and 12.00%(6/50)and the total effective rate was 82.00%(41/50).There was statistical significance(P<0.05).Conclusion Kangfuyan Capsule can obviously improve the clinical symptoms a

关 键 词：康妇炎胶囊 支原体属 慢性盆腔炎 炎症因子 盆腔血流动力学 

分 类 号：R271.911.33[医药卫生—中西医结合]