复方大七气汤联合TC方案治疗对晚期卵巢癌血清肿瘤标志物及免疫功能的影响  

Effects of Compound Daqiqi Decoction(复方大七气汤)Combined with TC Regimen on Serum Tumor Markers and Immune Function of Advanced Ovarian Cancer Patients

作　　者：康凌[1] 李小华[1] 宋晓玲[1] KANG Ling;LI Xiaohua;SONG Xiaoling(Nanyang Second People's Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳市第二人民医院,河南南阳473000

出　　处：《中华中医药学刊》2023年第3期38-41,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药行业科研项目(20190833998637)。

摘　　要：目的探讨复方大七气汤联合紫杉醇+卡铂(TC)方案治疗对晚期卵巢癌患者血清肿瘤标志物及免疫功能的影响。方法选取诊治的晚期卵巢癌患者80例,随机分为对照组与观察组,每组40例,采取TC化疗方案进行化疗,观察组患者同时联合复方大七气汤口服,治疗时间3个月,观察治疗前后中医证候积分变化,血清糖类抗原125(carbohydrate antigen 125,CA125)、糖类抗原199(carbohydrate antigen199,CA199)、人附睾分泌蛋白4(Human epididymis secretory protein E4,HE4)、B7同源体4(negative costimulatory molecule B7 homolog 4,B7-H4)、CD_(3)、CD_(4)、CD_(8)及NK细胞水平变化,治疗期间化疗药物不良反应发生情况。结果两组患者治疗前中医证候主症与次症积分比较差异均无统计学意义(P>0.05),治疗后积分低于治疗前(P<0.05),且观察组低于对照组(P<0.05);两组患者治疗前血清中CA125、CA199、HE4、B7-H4水平比较差异无统计学意义(P>0.05),治疗后低于治疗前(P<0.05),且观察组低于对照组(P<0.05);两组患者治疗前血清CD_(3)、CD_(4)、CD_(8)、NK细胞水平比较差异无统计学意义(P>0.05),治疗后低于治疗前(P<0.05),且对照组低于观察组(P<0.05);观察组血小板降低、白细胞降低、周围神经毒性及胃肠道反应发生率为65.00%、70.00%、30.00%、27.50%,低于对照组87.50%、92.50%、62.60%、60.00%,比较差异有统计学意义(P<0.05);观察组治疗疗效高于对照组(P<0.05),观察组治疗总有效率为72.50%,高于对照组50.00%,差异有统计学意义(P<0.05)。结论晚期卵巢癌患者在TC化疗方案基础上联合复方大七气汤治疗有助于提高患者免疫力,抑制血清肿瘤标志物,提高治疗疗效,降低化疗药物不良反应。Objective To explore the effects of Compound Daqiqi Decoction(复方大七气汤)combined with TC regimen on serum tumor markers and immune function of advanced ovarian cancer patients.Methods Eighty patients with advanced ovarian cancer were randomly divided into the control group and the observation group with 40 cases in each group.The control group was treated with taxol+carboplatin(TC)regimen and the observation group was treated with Compound Daqiqi Decoction combined with TC regimen.The treatment lasted for 3 months courses.The change of TCM symptom scores before and after treatment,serum levels of carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199),human epididymis protein 4(HE4)and B7 homolog 4(B7-H4),CD_(3),CD_(4),CD_(8)and NK cells and the occurrence of toxic and side effects of chemotherapy drugs during treatment were observed.Results There were no statistical significance in the scores of primary or secondary TCM symptoms between two groups before treatment(P>0.05).The scores of primary and secondary TCM symptoms after treatment were lower(P<0.001).The score of the observation group was lower than that of the control group(P<0.001).There were no statistical significance in serum levels of CA125,CA199,HE4 or B7-H4 between two groups before treatment(P>0.05).The serum levels of CA125,CA199,HE4 and B7-H4I after treatment were lower than those before treatment(P<0.001).Those of the observation group were lower than those of the control group(P<0.001).There were no statistical significance in serum CD_(3),CD_(4),CD_(8)or NK cells between two groups before treatment(P>0.05).The serum CD_(3),CD_(4),CD_(8)and NK cells after treatment were lower than those before treatment(P<0.001).Those of the control group were lower than those of the observation group(P<0.001).The incidence rates of thrombocytopenia,leukopenia,peripheral neurotoxicity and gastrointestinal reactions in the observation group were 65.00%,70.00%,30.00%and 27.50%,respectively.And those rates of the control group were 87.50%,92.50%,6

关 键 词：复方大七气汤 紫杉醇+卡铂方案 晚期卵巢癌 肿瘤标志物 免疫功能 

分 类 号：R273.373.1[医药卫生—中西医结合]