温针灸脾俞、肾俞对2型糖尿病糖脂代谢及氧化应激的影响  

Effect of Needle Warming Moxibustion at Pishu(BL20)and Shenshu(BL21)on Glucose and Lipid Metabolism and Oxidative Stress in Patients with Type 2 Diabetes

作　　者：张琳冬 沈创鹏[2] 刘敏[2] ZHANG Lindong;SHEN Chuangpeng;LIU Min(The First Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510000,Guangdong,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510000,Guangdong,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510000 [2]广州中医药大学第一附属医院,广东广州510000

出　　处：《中华中医药学刊》2023年第3期77-80,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82160891)。

摘　　要：目的探究温针灸脾俞、肾俞对2型糖尿病患者糖脂代谢及氧化应激的影响。方法选择2020年10月—2021年6月在医院就诊的236例2型糖尿病患者作为研究对象。采用随机数字表法将2型糖尿病患者分为两组:观察组(118例)和对照组(118例)。两组均给予针刺治疗,对照组在此基础上联合二甲双胍,观察组在对照组基础上温针灸脾俞、肾俞穴。治疗2个月后比较两组空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(2 h postprandial blood glucose,PBG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、甘油三酯(triglycerides,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-PX)和丙二醛(malondialdehyde,MDA)水平。结果观察组总有效率高于对照组[89.83%(106/118)vs 76.27%(90/118)],差异有统计学意义(P<0.05)。治疗后,观察组FBG、PBG、HbA1c、TC、TG、LDL-C和MDA水平均低于对照组,HDL-C和SOD水平高于对照组,差异均有统计学意义(P<0.05)。结论二甲双胍联合温针灸脾俞、肾俞治疗2型糖尿病,疗效显著,可有效改善糖脂代谢和氧化应激。Objective To explore the effects of needle warming moxibustion at Pishu(BL20)and Shenshu(BL21)on glucose and lipid metabolism and oxidative stress in patients with type 2 diabetes.Methods A total of 236 patients with type 2 diabetes who were treated in the hospital from October 2020to June 2021 were selected as the research objects.The random number table method was used to divide patients with type 2 diabetes into observation group(118 cases)and control group(118 cases).Both groups were given acupuncture treatment.The control group was combined with metformin on this basis,and the observation group was combined with needle warming moxibustion at Pishu(BL20)and Shenshu(BL21)on the basis of the control group.After 2 months of treatment,the two groups were compared the levels of fasting blood glucose(FBG),2 h postprandial blood glucose(PBG),glycosylated hemoglobin(HbA1c),triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),superoxide dismutase(SOD),glutathione peroxidase(GSH-PX)and malondialdehyde(MDA).Results The total effective rate of the observation group was higher than that of the control group[89.83%(106/118)vs 76.27%(90/118)],and the difference was statistically significant(P<0.05).After treatment,the levels of FBG,PBG,HbA1c,TC,TG,LDL-C and MDA in the observation group were lower than those in the control group,and the levels of HDL-C and SOD were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Metformin combined with needle warming moxibustion at Pishu(BL20)and Shenshu(BL21)for the treatment of type 2 diabetes has a significant effect and can effectively improve glucose and lipid metabolism and oxidative stress.

关 键 词：2型糖尿病 温针灸 脾俞 肾俞 糖脂代谢 氧化应激 

分 类 号：R259.872[医药卫生—中西医结合]