肠道菌群与2型糖尿病及中医药干预研究进展  

Research Progress on Gut Microbiota and Type 2 Diabetes Mellitus and Traditional Chinese Medicine Intervention

作　　者：董丽仙 尹爱武 李灿委 巫秀美 杨自忠 张成桂 高鹏飞 DONG Lixian;YIN Aiwu;LI Canwei;WU Xiumei;YANG Zizhong;ZHANG Chenggui;GAO Pengfei(College of Pharmacy,Dali University,Dali 671000,Yunnan,China;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Dali University,Dali 671000,Yunnan,China;Engineering Research Center of Exploitation and Comprehensive Utilization of Medicinal Insect Resources,Education Department of Yunnan Province,Dali 671000,Yunnan,China;Xiangtan Medicine and Health Vocational College,Xiangtan 411104,Hunan,China;College of Public Health,Dali University,Dali 671000,Yunnan,China)

机构地区：[1]大理大学药学院,云南大理671000 [2]云南省昆虫生物医药研发重点实验室,云南大理671000 [3]药用昆虫资源开发与综合利用云南省教育厅工程研究中心,云南大理671000 [4]湘潭医卫职业技术学院,湖南湘潭411104 [5]大理大学公共卫生学院,云南大理671000

出　　处：《中华中医药学刊》2023年第3期138-141,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81260676,82160798,81960712);中国国家留学基金项目(201708535007);云南省重大科技专项计划项目(202002AA100007)。

摘　　要：2型糖尿病(type 2 diabetes mellitus,T2DM)是临床上常见的代谢性疾病,发病机制复杂,随着患病率的逐年增加,引发了全球的广泛关注。研究表明肠道菌群紊乱与T2DM的发生发展之间存在一定关联性,肠道菌群代谢物、肠屏障改变和生物钟紊乱等均会影响T2DM的发生发展。研究证实中医药可以通过调节肠道菌群紊乱,达到一定的降低血糖的效果。对肠道菌群参与2型糖尿病的作用机制以及中医药通过调节肠道菌群治疗T2DM的研究进行总结,为以肠道菌群为切入点防治T2DM提供新的契机。Type 2 diabetes mellitus(T2DM)is a common metabolic disease in clinical practice.Its pathogenesis is complex,which has sparked widespread concern worldwide with the prevalence increasing.Numerous studies have shown that there is a correlation between gut microbiota disturbance and the occurrence and development of T2DM,and the metabolites of gut microbiota,changes of intestinal barrier and biological clock disturbance all affect the occurrence and development of T2DM.Studies have confirmed that traditional Chinese medicine can achieve a certain effect of lowering blood sugar by regulating gut microbiota disturbance.This paper summarized the mechanism of gut microbiota involved in T2DM and the research on the traditional Chinese medicine treatment of T2DM by regulating the gut microbiota,providing a new aspect for the prevention and treatment of T2DM by taking the gut microbiota as an entry point.

关 键 词：肠道菌群 2型糖尿病 作用机制 中医药 

分 类 号：R259.872[医药卫生—中西医结合]