基于痰瘀同治探讨麻杏化瘀汤对痰热闭肺型支气管肺炎患儿血清淀粉样蛋白含量的影响  

Effect of Maxing Huayu Decoction(麻杏化瘀汤)on SAA Content in Children with Phlegm-Heat Closing Lung Type of Bronchopneumonia Based on Simultaneous Treatment of Phlegm and Blood Stasis

作　　者：周维维[1] 李冬梅[1] 任耀全[1] 周黎黎[1] ZHOU Weiwei;LI Dongmei;REN Yaoquan;ZHOU Lili(Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,Gansu,China)

机构地区：[1]甘肃省中医院,甘肃兰州730050

出　　处：《中华中医药学刊》2023年第3期227-230,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：甘肃省中医药管理局项目(GZKP-2020-16)。

摘　　要：目的观察基于痰瘀同治探讨麻杏化瘀汤对痰热闭肺型支气管肺炎患儿血清SAA含量影响。方法研究纳入痰热闭肺型支气管肺炎患儿合计120例,均由医院2020年12月—2021年11月收治,将患者以随机数字表法分成对照组及观察组,每组60例,对照组患儿采取西医及小儿肺热咳喘口服液治疗,观察组患儿采取西医常规治疗+麻杏化瘀汤治疗,疗程7 d。数据观察:临床治疗效果、治疗前后中医证候积分(发热、有汗、咳嗽、气急喘促、呼吸困难、张口抬肩等)变化、血清淀粉样蛋白(serum amyloid A,SAA)水平变化、止咳及退热时间、气促消失时间及肺部体征消失时间、痊愈时间、治疗前后C反应蛋白(C-reactive protein,CRP)及白细胞(white blood cell,WBC)、降钙素原(procalcitonin,PCT)水平变化、免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白M(immunoglobulinM,IgM)水平变化、不良反应。结果观察组患儿治疗总有效率为96.67%(58/60),对照组为85.00%(51/60),观察组患儿有效率更高(P<0.05);两组患儿治疗前中医证候积分、SAA水平、WBC、PCT、CRP、IgA、IgG、IgM等指标比较,P>0.05,治疗后各组患儿中医证候积分、SAA水平、WBC、PCT、CRP、IgA、IgG、IgM等指标均改善,观察组患儿治疗后中医证候积分、SAA水平、WBC、PCT、CRP、IgA、IgG、IgM等指标优于对照组(P<0.05);与对照组患儿比较,观察组患儿退热时间、止咳时间、气促消失时间、肺部体征消失时间及痊愈时间均更短(P<0.05);两组不良反应发生率(对照组与观察组均为3.33%)均较低(P>0.05)。结论基于痰瘀同治给予痰热闭肺型支气管肺炎患儿麻杏化瘀汤治疗,取得较好临床治疗效果,患儿恢复好、恢复快,未见不良反应,安全可靠。Objective To observe the effect of Maxing Huayu Decoction(麻杏化瘀汤)on serum amyloid A(SAA)content in children with phlegm-heat closing lung type of bronchopneumonia based on the simultaneous treatment of phlegm and blood stasis.Methods A total of 120 cases with phlegm-heat closing lung type of bronchopneumonia in the hospital from December 2021 to November 2020,according to the random number table method,were divided into control group and observation group,60 cases in each group.The control group was treated with western medicine and Xiaoer Feire Kechuan Oral Liquid(小儿肺热咳喘口服液).The observation group was treated with conventional western medicine treatment+Maxing Huayu Decoction.The treatment course lasted for 7 days.The clinical treatment effect,the changes of TCM syndrome scores(fever,sweating,cough,shortness of breath,dyspnea,mouth opening and shoulder lifting,etc.)before and after treatment,the SAA level,cough relieving and fever relieving time,dyspnea disappearance time,pulmonary signs disappearance time,recovery time,the levels of C-reactive protein(CRP)and white blood cell(WBC)before and after treatment,the levels of procalcitonin(PCT),immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)and adverse reactions of two groups were compared.Results The total effective rate was 96.67%(58/60)in the observation group and 85.00%(51/60)in the control group.The effective rate was higher in the observation group(P<0.05).Comparison of TCM syndrome scores,SAA level,WBC,PCT,CRP,IgA,IgG,IgM and other indicators between two groups before treatment had no significance(P>0.05).After treatment,TCM syndrome scores,SAA level,WBC,PCT,CRP,IgA,IgG,IgM and other indicators were improved in two groups.After treatment,TCM syndrome scores,SAA level,WBC,PCT,CRP,IgA,IgG,IgM and other indicators in the observation group were better than those in the control group(P<0.05).Compared with those of the control group,the fever reduction time,cough relief time,shortness of breath disappearance time,pulmonary

关 键 词：支气管肺炎 患儿 痰热闭肺型 麻杏化瘀汤 西医常规治疗 疗效 不良反应 

分 类 号：R259.631[医药卫生—中西医结合]