基于真实世界数据的莪术油注射液临床用药特征分析  

Analysis of clinical medication characteristics of zedoary turmeric oil injection based on real world data

作　　者：李心怡 武玉卓 杨基举 周园园 田贵华[1] LI Xin-yi;WU Yu-zhuo;YANG Ji-ju;ZHOU Yuan-yuan;TIAN Gui-hua(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;School of Pharmacy,Anhui Medical University,Hefei 230032,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]安徽医科大学药学院,合肥230032

出　　处：《中国新药杂志》2023年第5期547-552,共6页Chinese Journal of New Drugs

摘　　要：目的:基于真实世界数据分析莪术油注射液临床用药特征,为其临床合理用药提供参考。方法:基于全国12家医院HIS(hospital information system)系统中提取的894例接受莪术油注射液治疗的病例数据,采用频数分析方法对患者一般性资料和用药情况进行描述分析,并利用VOSviewer软件结合Python程序对894例患者原患疾病和联合用药情况进行可视化关联分析。结果:894例使用莪术油注射液患者中,诊断为上呼吸道感染的频率最高,治疗总体有效率达99.55%;894例病例数据中超过说明书规定滴速使用的病例占11.52%,报告不良反应3例。在莪术油注射液联合用药方面,溶媒主要以5%葡萄糖注射液(73.60%)为主且多与热毒宁注射液、盐酸氨溴索注射液等联用。结论:莪术油注射液在呼吸系统和消化系统相关疾病治疗中具有重要的应用价值,但目前现有数据资料有限,莪术油注射液临床应用的有效性和安全性仍需要进一步完善。加强中药注射液上市后有效性和安全性再评价工作,对莪术油注射液等中药注射液的临床合理用药提供更高质量证据支撑。Objective:To analyze the clinical medication characteristics of zedoary turmeric oil injection based on real world data,and to provide reference for its clinical rational medication.Methods:Based on the data of 894 cases treated with zedoary turmeric oil injection extracted from the HIS system of 12 hospitals in China,the general data and medication status of the patients were described and analyzed by using frequency analysis method.The visual correlation analysis of the original diseases and combined medication status of 894 patients was carried out by using VOSviewer software and python program.Results:Among 894 patients who were administered zedoary turmeric oil injection,the frequency of upper respiratory tract infection was the highest,and the overall effective rate of treatment was 99.55%.Among the 894 cases,11.52%were over the prescribed dropping rate,and 3 cases of adverse reactions were reported.In the aspect of combined use of zedoary turmeric oil injection,the solvent is mainly 5%glucose injection(73.60%),and it is mostly combined with Reduning injection and ambroxol hydrochloride injection.Conclusion:zedoary turmeric oil injection has important application value in the treatment of respiratory and digestive system-related diseases.However,there are occasional mild adverse events,which may be related to the non-standard infusion operation.The existing data is limited,and the effectiveness and safety of zedoary turmeric oil injection in clinical application still need to be further improved.The reevaluation of the effectiveness and safety of traditional Chinese medicine injection should be strengthened after being listed.Also,higher quality evidence support should be provided for the clinical rational use of traditional Chinese medicine injection such as zedoary turmeric oil injection.

关 键 词：真实世界数据 莪术油注射液 临床用药分析 

分 类 号：R969.3[医药卫生—药理学]