坏死性凋亡在动脉粥样硬化及相关疾病中的作用  

Role of necroptosis in atherosclerosis and related diseases

作　　者：白潇萱 贾海波[1] BAI Xiao-xuan;JIA Hai-bo(Department of Cardiology,Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150081,China)

机构地区：[1]哈尔滨医科大学附属第二医院心内科,黑龙江哈尔滨150081

出　　处：《心血管康复医学杂志》2023年第2期134-138,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：国家自然科学基金(82072031)。

摘　　要：坏死性凋亡是近年发现的一种新的细胞程序性死亡方式,其形态特征与细胞坏死相似,却存在规律的调控机制。新近研究表明,坏死性凋亡参与了多种疾病的发生发展,在心血管疾病尤其是动脉粥样硬化性疾病中也发挥重要作用。本文就坏死性凋亡在动脉粥样硬化、心肌缺血再灌注损伤及心肌梗死中的作用及研究进展作一综述。Necroptosis is a new way of programmed cell death discovered in recent years.Its morphological characteristics are similar to necrosis,but there is a regular regulatory mechanism.Recent studies have shown that necroptosis is involved in the occurrence and development of a variety of diseases and also plays an important role in cardiovascular diseases,especially atherosclerotic diseases.This article reviews the role and research progress of necroptosis in atherosclerosis,myocardial ischemia-reperfusion injury and myocardial infarction.

关 键 词：动脉粥样硬化 细胞凋亡 心肌梗死 

分 类 号：R543.5[医药卫生—心血管疾病]