透明细胞丘疹病57例临床特征分析  

Clinical characteristics of 57 cases of clear cell papulosis

作　　者：任发亮[1,2] 王华 肖异珠[1] Ren Faliang;Wang Hua;Xiao Yizhu(Department of Dermatology,Children′s Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院皮肤科、国家儿童健康与疾病临床医学研究中心、儿童发育疾病研究教育部重点实验室、儿科学重庆市重点实验室,重庆400014 [2]重庆医科大学附属第一医院皮肤科,重庆400017

出　　处：《中华皮肤科杂志》2023年第4期309-312,共4页Chinese Journal of Dermatology

摘　　要：目的总结透明细胞丘疹病的临床及病理特征。方法收集重庆医科大学附属儿童医院皮肤科2014年11月至2022年3月诊断的57例透明细胞丘疹病患儿的临床资料,分析临床及病理特征。结果57例患儿中,男30例,女27例;年龄6个月至7岁10个月;发病年龄1~74个月,39例(68.4%)于婴儿期发病;病程1~84个月。皮疹主要表现为粟粒至黄豆大小类圆形白色斑疹或1~2 cm短条状白色斑疹。49例(85.9%)皮疹数量<20个。好发部位依次为下腹部(35例,61.4%)、胸前或上腹部(34例,59.6%)、腋前或腋下(17例,29.8%)、外阴(11例,19.3%)。胸前或上腹部、腋前或腋下的皮疹以短条状白色斑疹相对多见[23/34例(65.7%)、10/17例],下腹部皮疹以类圆形白色斑疹占明显优势[30/35例(85.7%)],外阴皮疹都表现为类圆形白色斑疹。组织病理表现为表皮基底层或基底层上方散在的胞质丰富淡染体积稍大的细胞,这些细胞CK7阳性、癌胚抗原阳性和过碘酸希夫染色阳性。结论透明细胞丘疹病患病年龄小,下腹部和外阴的皮疹大多是类圆形白色斑疹,胸前或上腹部、腋前或腋下的皮疹以短条状白色斑疹相对多见,有较强的临床识别特征。Objective To analyze and summarize clinical and pathological characteristics of clear cell papulosis(CCP).Methods Clinical data were collected from 57 children with CCP,who were diagnosed in Department of Dermatology,Children′s Hospital of Chongqing Medical University from November 2014 to March 2022,and their clinical and pathological characteristics were analyzed.Results Among the 57 patients,30 were males and 27 were females;their age ranged from 6 months to 7 years and 10 months;the age at onset ranged from 1 to 74 months,and 39(68.4%)experienced onset of disease in infancy;the course of disease ranged from 1 to 84 months.Skin lesions mainly manifested as millet-to soybean-sized roundish white macules or short bar-like white macules measuring 1-2 cm in length.Most patients(49 cases,85.9%)had skin lesions less than 20 in number.The most common location of skin lesions was the lower abdomen(35 cases,61.4%),followed in turn by chest or upper abdomen(34 cases,59.6%),anterior axilla or armpit(17 cases,29.8%),and vulva(11 cases,19.3%).Short bar-like white macules predominated on the chest or upper abdomen(23/34,65.7%)and anterior axilla or armpit(10/17),roundish white macules predominated on the lower abdomen(30/35,85.7%),and the vulvar lesions all manifested as roundish white macules.Histopathological findings showed that slightly larger cells with abundant clear cytoplasm were scattered in or above the basal layer of the epidermis,and these cells were positive for cytokeratin 7,carcinoembryonic antigen,and periodic acid-Schiff staining.Conclusion CCP mainly occurred in young children,roundish white macules predominated on the lower abdomen and vulva,and short bar-like white macules predominated on the chest or upper abdomen,as well as on the anterior axilla or armpit,indicating that CCP has strongly identifiable clinical features.

关 键 词：白斑 儿童 皮肤表现 病理过程 透明细胞丘疹病 临床特征 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]