过氧化物酶体增殖物激活受体γ对皮肤生理功能和病理过程的影响  

Effect of peroxisome proliferator-activated receptorγon skin physiological and pathological processes

作　　者：连盼盼 刘军[2] 苏忠兰[3] 王宏伟[1] Lian Panpan;Liu Jun;Su Zhonglan;Wang Hongwei(Medical School of Nanjing University,State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine,Nanjing 210093,China;Department of Dermatology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210093,China;Department of Dermatology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京大学医学院生命分析化学国家重点实验室和江苏省分子医学重点实验室,210093 [2]南京大学医学院附属鼓楼医院皮肤科,210093 [3]南京医科大学第一附属医院皮肤科,210029

出　　处：《中华皮肤科杂志》2023年第4期365-368,共4页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81773326);江苏省自然科学基金(BE2019676、BK20171117);南京市医学科技发展项目(YKK17081)。

摘　　要：过氧化物酶体增殖物激活受体(PPAR)广泛参与机体的脂质代谢、糖代谢、细胞生长分化以及炎症发生等过程。PPARγ激动剂可抑制皮肤炎症反应,保护表皮屏障功能,修复损伤。本文总结PPARγ在皮肤生物学中的不同作用,讨论其在银屑病和皮肤肿瘤等疾病中的作用。Peroxisome proliferator-activated receptors(PPARs)are widely involved in lipid metabolism,glucose metabolism,cell growth and differentiation,and inflammation in the human body.PPARγagonists can inhibit skin inflammatory response,protect epidermal barrier function,and repair skin injury.This review summarizes various roles of PPARγin skin biology,and discusses its function in skin diseases,such as psoriasis and skin tumors.

关 键 词：过氧化物酶体增殖物激活受体 炎症 创伤和损伤 皮肤衰老 皮肤肿瘤 银屑病 

分 类 号：R751[医药卫生—皮肤病学与性病学]