微生物群体感应系统在皮肤炎症发展中的作用机制  

Mechanism of action of the microbial quorum-sensing system in the development of skin inflammation

作　　者：周园 姚煦 Zhou Yuan;Yao Xu(Department of Allergy and Rheumatology,Hospital of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China)

机构地区：[1]中国医学科学院、北京协和医学院皮肤病医院过敏与风湿免疫科,南京210042

出　　处：《中华皮肤科杂志》2023年第4期372-375,共4页Chinese Journal of Dermatology

基　　金：国家自然科学基金(82073446);江苏省社会发展重大项目(BE2020632);南京市国家级临床医学中心培育计划(2019060001);中国医学科学院医学与健康科技创新工程项目(2016-I2M-1-005)。

摘　　要：群体感应系统是一种依赖于群体密度变化的细胞间通信方式,与皮肤菌群的变化及致病性密切相关。金黄色葡萄球菌致病毒力因子的合成受辅助基因调节(Agr)群体感应系统调控。各类皮肤共生菌如凝固酶阴性葡萄球菌、棒状杆菌属可通过抑制金黄色葡萄球菌的Agr群体感应系统,抑制毒力因子合成,减轻皮肤炎症。本文综述微生物群体感应系统在皮肤炎症中的作用机制及各类群体感应抑制剂。Quorum-sensing system is a way of communication between cells that depends on changes in population density of microorganisms,and is closely associated with variety and pathogenicity of skin microbiota.The synthesis of virulence factors of Staphylococcus aureus(S.aureus)is regulated by the accessory gene regulator(Agr)quorum-sensing system.Various skin commensals such as coagulase-negative Staphylococcus and Corynebacterium can inhibit the Agr quorum-sensing system of S.aureus,thus decrease the synthesis of virulence factors and attenuate skin inflammation.This review summarizes the mechanism of action of microbial quorum-sensing system in skin inflammation and various quorum-sensing inhibitors.

关 键 词：群体感应 微生物群落 皮炎 特应性 金黄色葡萄球菌 群体淬灭 

分 类 号：R751[医药卫生—皮肤病学与性病学]