响应面法优化微通道反应器中巴柳氮的合成工艺  

Optimization of synthesis process of balsalazide in microchannel reactor by response surface methodology

作　　者：刘亚祺 刘泽宇 朱晓磊 杜会茹[1,2] LIU Ya-qi;LIU Ze-yu;ZHU Xiao-lei;DU Hui-ru(Hebei Chemical and Pharmarceutical College Department of Pharmarceutical Engineering,Shijiazhuang 050026,China;Project Supported by Hebei Technological Innovation Center of Chiral Medicine,Shijiazhuang 050026,China)

机构地区：[1]河北化工医药职业技术学院制药工程系,河北石家庄050026 [2]河北省手性药物技术创新中心,河北石家庄050026

出　　处：《精细与专用化学品》2023年第3期47-50,共4页Fine and Specialty Chemicals

基　　金：河北省科技厅项目(22E50186D)。

摘　　要：以N-对氨基苯甲酰-β-丙氨酸为原料,利用Box-Behnken设计-响应面法优化微通道反应器中巴柳氮合成工艺,采用Box-Behnken设计试验优化重氮化反应停留时间、水杨酸量以及偶合反应停留时间对巴柳氮产率的影响,并对合成工艺进行优化。结果表明,微通道反应器内巴柳氮反应最优条件为:重氮化反应停留时间为21.15s、水杨酸量0.24mol、偶合反应停留时间172.64s,巴柳氮产率为89.01%,与模型预测值仅相差0.35%。该工艺可为巴柳氮工业化生产改进提供一定的参考。Using N-(4-aminobenzoyl)-β-alaninee as raw materials,taking the diazotization reaction time,salicylic acid amount,and coupling reaction time on the balsalazide synthesis yield in microchannel reactor was optimized of by Box-Behnken design experiment.The experiment made was aimed at obtaining the optimal balsalazide synthesis process conditions,the diazotization reaction time was 21.15s,the salicylic acid amount was 0.24mol,and coupling reaction time was 172.64s,product yield was 89.01%.The difference with the predicted value was only 0.35%.This process provided some experimental data for the improvement of industrial production of baluazine.

关 键 词：巴柳氮 BOX-BEHNKEN设计 响应面 微通道反应器 

分 类 号：TQ463[化学工程—制药化工]