鞘氨醇激酶和1-磷酸鞘氨醇及其受体信号在肿瘤微环境中的研究进展  

Research progress of sphingosine kinase and sphingosine-1-phosphate(S1P)/S1P receptor signaling in tumor microenvironment

作　　者：韦曦华 王泽群 陈靖京 潘燕[1] WEI Xi-hua;WANG Ze-qun;CHEN Jing-jing;PAN Yan(School of Basic Medical Sciences,Health Science Center,Peking University,Beijing 100191,China)

机构地区：[1]北京大学医学部基础医学院,北京100191

出　　处：《药学学报》2023年第3期571-580,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81773765)。

摘　　要：鞘氨醇激酶(SphK)、1-磷酸鞘氨醇(S1P)及其受体(S1PR)参与肿瘤细胞增殖、迁移等生物学过程,在癌症的发生发展中起重要作用。近年来,研究者日益关注癌细胞与肿瘤微环境之间的相互作用,肿瘤微环境具有遗传稳定性并且能够被诱导为抗肿瘤表型,具有显著的治疗优势。研究显示,SphK/S1P/S1PR能够调节肿瘤微环境的多个方面。本文从肿瘤免疫微环境、癌症相关成纤维细胞、肿瘤血管生成、肿瘤缺氧微环境4个角度对SphK和S1P/S1PR信号对肿瘤微环境的影响进行综述,并简要概述相关药物研究情况,旨在阐明SphK/S1P/S1PR在癌症中的作用及为抗肿瘤药物的研究提供新思路。Sphingosine kinase(SphK),sphingosine-1-phosphate(S1P)and S1P receptor(S1PR)are involved in the tumor biological processes such as tumor cell proliferation and migration,and play an important role in the development of cancer.In recent years,researchers have increasingly focused on the interaction between cancer cells and the tumor microenvironment.The tumor microenvironment is genetically stable and can be induced to an antitumor phenotype,which has significant therapeutic advantages.Studies have shown that SphK/S1P/S1PR can regulate multiple aspects of the tumor microenvironment.This review summarizes the effects of SphK and S1P/S1PR signaling on the tumor microenvironment from four perspectives:tumor immune microenvironment,cancer associated fibroblasts,tumor angiogenesis and tumor hypoxic microenvironment,and also outlines potential drug research related to these signal molecules,aiming to elucidate the role of SphK/S1P/S1PR in tumor occurrence and development and provide new ideas for the research of anti-tumor drugs.

关 键 词：肿瘤微环境 鞘氨醇激酶 1-磷酸鞘氨醇 1-磷酸鞘氨醇受体 抗肿瘤药物 

分 类 号：R966[医药卫生—药理学]