蓬莪术中一个新的榄香烷型倍半萜苷  

A new elemane-type sesquiterpenoid glycoside from Curcuma phaeocaulis

作　　者：李承哲 彭成[1] 李小翠 刘娟[1,2] 周勤梅 蒙春旺[1,2] 刘菲 熊亮 LI Cheng-zhe;PENG Cheng;LI Xiao-cui;LIU Juan;ZHOU Qin-mei;MENG Chun-wang;LIU Fei;XIONG Liang(State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院,西南特色中药资源国家重点实验室,四川成都611137 [2]成都中医药大学西南特色药材创新药物成分研究所,四川成都611137 [3]成都中医药大学中医药创新研究院,四川成都611137

出　　处：《药学学报》2023年第3期736-739,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金青年基金项目(81903777,82104371);国家自然科学基金优秀青年基金项目(82022072);国家中医药多学科交叉创新团队项目(ZYYCXTD-D-202209)。

摘　　要：为研究蓬莪术Curcuma phaeocaulis根茎中化学成分及其生物活性,采用硅胶柱色谱、反相中压液相色谱、制备薄层色谱及半制备高效液相色谱等技术进行分离纯化,运用现代波谱学手段鉴定化合物的结构。同时采用MTT法测定了化合物对HUVECs细胞增殖的影响。从蓬莪术根茎95%乙醇提取物的正丁醇萃取部位分离得到1个新的榄香烷型倍半萜苷,鉴定为(1Z)-2-羟基-莪术酮2-O-β-D-葡萄糖苷,该化合物对HUVECs细胞增殖无明显抑制作用。To study the chemical constituents and their biological activities in the rhizomes of Curcuma phaeocaulis,silica gel column chromatography,reverse medium pressure liquid chromatography,preparative thin layer chromatography,and semi-preparative high performance liquid chromatography were used for isolation and purification and modern spectroscopic methods were used to determine the structure of the isolated compound.Moreover,the effect of the compound on the proliferation of HUVECs was determined by the MTT assay.A new elemane-type sesquiterpenoid glycoside was isolated from the n-butanol soluble fraction of 95% ethanolic extract of the rhizomes of Curcuma phaeocaulis.Its structure was identified as(1Z)-2-hydroxy-curzerenone 2-O-β-Dglucoside.It showed no inhibitory effect on the proliferation of HUVECs.

关 键 词：蓬莪术 倍半萜苷 榄香烷型 分离鉴定 

分 类 号：R284[医药卫生—中药学]