桂芍香芷方治疗十二指肠球部溃疡患者临床疗效及对生活质量的影响  

Effect of GuishaoXiangzhi Recipe(桂苟香芷方)on Clinical Efficacy and Quality of Life of Patients with Duodenal Bulb Ulcer

作　　者：黄晓春[1] 乔晓[1] HUANG Xiaochun;QIAO Xiao(Huai'an Second People's Hospital,Huai'an 223001,Jiangsu,China)

机构地区：[1]淮安市第二人民医院,江苏淮安223001

出　　处：《辽宁中医杂志》2023年第2期145-148,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：江苏省卫生厅基金项目(Z201317)。

摘　　要：目的观察桂芍香芷方治疗十二指肠球部溃疡患者临床疗效及对生活质量的影响。方法共计纳入淮安市第二人民医院收治的十二指肠球部溃疡患者91例(2019年9月—2021年9月),以随机数字表法分成干预组(46例)与参照组(45例),参照组患者实施临床常规干预,干预组患者在参照组干预基础上给予患者桂芍香芷方干预,数据观察:幽门螺杆菌(Hp)清除率、疗效、干预前后中医证候(胃脘隐痛、喜暖喜按、四末不温、面色不华、食少便溏等)积分变化、胃电图指标变化、胃肠道激素水平变化、生活质量(QLQ-C30)量表评分变化及不良反应。结果与参照组比较,干预组患者Hp清除率更高,治疗总有效率更高(均P<0.05);干预前,两组患者中医证候(胃脘隐痛、喜暖喜按、四末不温、面色不华、食少便溏等)积分、胃电图指标及胃肠道激素水平、QLQ-C30评分等指标对比,差异无统计学意义(P>0.05),干预后两组患者中医证候(胃脘隐痛、喜暖喜按、四末不温、面色不华、食少便溏等)积分、胃电图指标及胃肠道激素水平、QLQ-C30评分等指标均改善,干预组患者中医证候(胃脘隐痛、喜暖喜按、四末不温、面色不华、食少便溏等)积分、胃电图指标及胃肠道激素水平、QLQ-C30评分等指标优于参照组(P<0.05);两组患者均未见严重不良反应。结论桂芍香芷方可一定程度提升十二指肠球部溃疡患者疗效及生活质量,患者Hp清除率高,症状缓解,胃肠功能恢复较好,未见不良反应,安全可靠。Objective To observe the effect of Guishao Xiangzhi Recipe(桂香芷方)on the clinical efficacy and quality of life of patients with duodenal bulb ulcer.Methods A total of 91 patients with duodenal ulcer admitted to the Second People's Hospital of Huai'an(September 2019 to September 2021)were randomly divided into intervention group(46 cases)and control group(45 cases).The patients in the control group received routine clinical intervention.Those in the intervention group were given Guishao Xiangzhi Recipe on the basis of the intervention in the control group.Helicobacter pylori(Hp)clearance rate,efficacy before and after the intervention,the integral changes of TCM syndromes(epigastric pain,perferring being warmed and pressed,not warm at the end of the four limbs,not bright complexion,loose stools due to lack of food),electrogastrogram indicators,gastrointestinal hormone levels,quality of life(QLQ-C30)scale scoresand adverse reactions were compared.Results Compared with those of the control group,the clearance rate of Hp in the intervention group was higher and the total effective rate was higher(both P<0.05).Before the intervention,there was no statistically significant difference between the two groups in terms of scores of TCM syndromes(epigastric pain,perferring being warmed and pressed,not warm at the end of the four limbs,not bright complexion,loose stools due to lack of food),electrogastrogram indicators,gastrointestinal hormone levels,QLQ-C30 scores and other indicators had no significance(P>0.05).After the intervention,there wasstatistically significant difference between the two groups in terms of scores of TCM syndromes(epigastric pain,perferring being warmed and pressed,not warm at the end of the four limbs,not bright complexion,loose stools due to lack of food),electrogastrogram indicators and gastrointestinal hormone levels.The scores of QLQ-C30 and other indicators were improved,and the scores of TCM syndromes(epigastric pain,perferring being warmed and pressed,not warm at the end of the four lim

关 键 词：十二指肠球部溃疡 Hp清除率 桂芍香芷方 疗效 生活质量 不良反应 

分 类 号：R45[医药卫生—治疗学]