调和肝脾类中药治疗“肠-肝”轴相关疾病作用机制的研究进展  

Research progress on mechanism of traditional Chinese medicine with harmonizing liver and spleen in treatment of“gut-liver”axis related diseases

作　　者：贾可欣 李寒 刘闰平 JIA Ke-xin;LI Han;LIU Run-ping(School of Chinese Material Medica,Beijing University of Chinese Medicine,Beijing 100029,China;School of Life Science,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学中药学院,北京100029 [2]北京中医药大学生命科学学院,北京100029

出　　处：《中草药》2023年第5期1609-1619,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82004029);中华中医药学会青年人才托举工程项目(2020-QNRC2-01)。

摘　　要：“肠-肝”轴相关疾病是一类基于肝脏和肠道相互作用失衡而引起或加重的疾病。传统中医学基于五脏整体观对“肠-肝”轴相关疾病的认知延伸了自身的肝脾概念,调和肝脾类中药对“肠-肝”轴相关疾病亦有积极的治疗效果,契合中医“肝脾同调,治肝实脾”的独特理念。通过对调和肝脾类中药调节肠道微生态及免疫微环境、保护肠道机械屏障、平衡胆汁酸稳态、调节神经递质治疗“肠-肝”轴相关疾病进行系统性回顾,为从“肠-肝”轴角度阐释调和肝脾类中药的现代科学内涵提供新的思路,助力创新中药开发。“Gut-liver”axis related diseases are induced and exacerbated by unbalanced interaction between liver and intestine.The unique cognition of“gut-liver”axis diseases,which is based on the“holism of five organs”theory,extended the concept of liver and spleen in traditional Chinese medicine,with the effective therapies of harmonizing the liver and spleen and correlative representative prescriptions in clinical,which also tallied with the consensus of“harmonizing the liver and spleen,curing the liver to reinforcing spleen”in traditional Chinese medicine.Therefore,the review aims to offer an innovative therapeutic perspective for the“gut-liver”axis diseases and help the creative exploitation of traditional Chinese medicine by elaborating the scientific connotation of prescriptions and herbs that harmonize the liver and spleen,which through adjusting the intestinal microecology and immune microenvironment,protecting the intestinal mechanical barrier,maintaining the bile acid homeostasis and regulating the neurotransmitter.

关 键 词：“肠-肝”轴 调和肝脾 以肝治肠 以肠治肝 肝肠同治 

分 类 号：R285[医药卫生—中药学]