槲皮素的结构修饰及生物活性研究进展  

Research progress on structural modification and biological activity of quercetin

作　　者：李阳杰 曹瑞梅 毛雅君 邵香敏 冯亚莉 翟广玉 LI Yang-jie;CAO Rui-mei;MAO Ya-jun;SHAO Xiang-min;FENG Ya-li;ZHAI Guang-yu(School of Pharmacy and Chemical Engineering,Zhengzhou Institute of Technology,Zhengzhou 450041,China)

机构地区：[1]郑州工业应用技术学院药学与化学工程学院,河南郑州450041

出　　处：《中草药》2023年第5期1636-1653,共18页Chinese Traditional and Herbal Drugs

基　　金：郑州市高等学校名师技术技能工作室(郑教高[2015]70号):教育部产学研协同育人项目(202102028026)。

摘　　要：槲皮素是蔬菜、水果、中药中常见的黄酮类化合物,是天然的抗氧化剂,具有抗癌、抗糖尿病、抗菌、抗炎、抗病毒等生物活性。由于槲皮素生物利用度低,限制了其在临床上的应用。通过各种方法设计和合成新的槲皮素衍生物,以改善其缺点,进而发挥预防和治疗疾病的作用。通过对槲皮素衍生物的合成及其抗癌、抗糖尿病、抗炎、抗菌和抗病毒活性进行综述,并对其构效关系进行分析,为天然化合物的开发和利用奠定基础。Quercetin is a common flavonoid found in vegetables,fruits and traditional Chinese medicine.It is a natural antioxidant with anti-cancer,anti-diabetes,antibacterial,anti-inflammatory,anti-virus and other biological activities.The low bioavailability of quercetin limits its clinical application.New quercetin derivatives were designed and synthesized by various methods to improve their shortcomings and thus play a role in the prevention and treatment of diseases.By reviewing the synthesis and anti-cancer,anti-diabetes,anti-inflammatory,antibacterial and antiviral activities of quercetin derivatives,and analyzing their structure-activity relationship,we lay a foundation for the development and utilization of natural compounds.

关 键 词：槲皮素 羟基修饰 羰基修饰 衍生物 抗癌 抗糖尿病 构效关系 

分 类 号：R282.710.85[医药卫生—中药学]