穴位敷贴治疗合并过敏性鼻炎哮喘的疗效评价及对血清IL-33的影响  

Evaluation of Curative Effect of Acupoint Application in Treatment of Allergic Rhinitis and Asthma and The Effect of Serum IL-33

作　　者：窦迎婷[1,2] 朱振刚 狄冠麟[1,2] DOU Yingting;ZHU Zhengang;DI Guanlin(The First Affliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300380,China;National Clinical Research Center of Chinese Acupuncture and Moxibustion,Tianjin 300380,China)

机构地区：[1]天津中医药大学第一附属医院,天津300380 [2]国家中医针灸临床医学研究中心,天津300380

出　　处：《辽宁中医杂志》2023年第3期177-180,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：天津中医药大学第一附属医院“拓新工程”基金科研课题(201912)。

摘　　要：目的 探讨中医外治法联合西医治疗合并过敏性鼻炎哮喘的临床疗效及对血清白细胞介素33(IL-33)的影响。方法 将60例过敏性鼻炎哮喘患者随机分为两组。穴位敷贴组30例,予中药穴位敷贴联合西医基础治疗;西药组30例,予常规西药治疗。评价两组患者急性发作次数、感染次数、肺功能、哮喘症状控制水平(ACT)、哮喘生存质量(AQLQ)、视觉模拟评分(VAS)及血清IL-33水平。结果 两组患者治疗前后血清IL-33改善情况具有统计学意义(P=0.000<0.05);穴位贴敷组患者急性发作次数、感染次数较去年有明显降低;西药组无明显变化(P>0.05)。治疗前后,穴位敷贴组ACT三个等级差异有统计学意义(P=0.032<0.05);两组比较有统计学意义(P<0.05)。穴位敷贴组组内比较,除AQLQ-心理(P=0.126>0.05)、AQLQ-刺激原(P=0.169>0.05)、AQLQ-自我关心(P=0.130>0.05)外,其余均差异具有统计学意义(P<0.05);两组组间比较差异无统计学意义(P>0.05)。治疗后穴位敷贴组除流涕、鼻痒症状外,喷嚏、鼻塞均有改善,且与单纯西药组对比,差异具有统计学意义;肺功能:治疗后两组组间进行比较差异无统计学意义(P>0.05)。结论 穴位敷贴联合西药常规治疗可明显减少患者急性发作次数,哮喘控制情况得到改善、过敏性鼻炎症状,可改善患者肺功能、生活质量,疗效优于单纯西药治疗,并且可下调血清IL-33水平。Objective To explore the clinical efficacy of external treatment of traditional Chinese medicine combined with Western medicine in the treatment of asthma complicated with allergic rhinitis and the influence of serum IL-33.Methods Sixty patients with allergic rhinitis and asthma were randomly divided into two groups.Acupoint application group(30 cases) received acupoint application combined with western medicine basic treatment.Western medicine group(30 cases) were treated with conventional western medicine.The number of acute attacks, the number of infections, lung function, asthma symptom control level(ACT),asthma quality of life(AQLQ),visual analogue scale(VAS) and serum IL-33 level were evaluated in two groups.Results The improvement of serum IL-33 in two groups before and after treatment was statistically significant(P=0.000<0.05).The number of acute attacks and infections in the acupoint application group was significantly lower than last year.There was no significant change in western medicine group(P>0.05).Before and after treatment, the analysis of three grades of ACT in acupoint application group showed significance(P=0.032<0.05).The difference of the two groups was significant(P=0.017<0.05).Except for AQLQ-psychology(P=0.126>0.05),AQLQ-stimulator(P=0.169>0.05),AQLQ-self-care(P=0.130>0.05),there were statistically significant differences in other terms(P<0.05).There was no significant difference between the two groups(P>0.05).After treatment, except for runny nose and itching nose, sneezing and nasal obstruction were improved in the acupoint application group, and the difference was statistically significant compared with the western medicine group.After treatment, lung function test values of the two groups were not significant(P>0.05).Conclusion Acupoint application combined with conventional treatment of Western medicine can significantly reduce the number of acute attacks, improve the control of asthma and allergic rhinitis symptoms as well as the lung function and quality of life of patients.The cu

关 键 词：哮喘 过敏性鼻炎 过敏性鼻炎-哮喘综合征 穴位敷贴 白细胞介素-33 疗效评价 

分 类 号：R562.25[医药卫生—呼吸系统]