孕晚期血尿酸水平对母婴结局的影响  

The Influence of Blood Uric Acid Level in the Third Trimester of Pregnancy on the Maternal and Infant Outcome

作　　者：卢永收 LU Yongshou(Linyi Maternal and Child Health Care Hospital,Shandong Province,Linyi 276000,China)

机构地区：[1]临沂市妇幼保健院产科,山东临沂276000

出　　处：《中国医药指南》2023年第11期21-24,共4页Guide of China Medicine

摘　　要：目的 分析孕晚期血尿酸(BUA)水平对母婴结局的影响。方法 选取2020年7月至2021年7月于我院顺利分娩的770例妊娠妇女为研究对象,依据妇女孕晚期BUA水平将其分为高尿酸组(≥357μmol/L,n=77)和正常组(<357μmol/L,n=693),比较两组孕妇和新生儿的不良妊娠结局情况。并依据是否发生不良妊娠结局将孕妇分为不良组(n=253)和对照组(n=517),比较两组孕妇的各项一般资料和孕晚期临床资料,并对有意义的因素行Logistic多因素分析,明确妊娠妇女出现不良妊娠结局的危险因素,并Pearson分析孕晚期BUA与各危险因素的相关性。结果 高尿酸组孕妇的妊娠合并症、低蛋白血症、胸腹腔积液、心功能不全、肝功能不全、肾功能不全的发生率均高于正常组,高尿酸组新生儿医源性早产、胎儿窘迫、窒息、低出生体质量、死亡的发生率均高于正常组,差异统计学有意义(P <0.05)。Logistic多因素分析结果显示,收缩压、血肌酐、BUA、丙氨酸氨基转移酶水平高,白蛋白水平低为妊娠妇女出现不良妊娠结局的危险因素(P <0.05)。孕晚期BUA与收缩压、孕前体质量指数、血肌酐、丙氨酸氨基转移酶水平均呈现正相关(P <0.05),与白蛋白呈现负相关(P <0.05)。结论 高尿酸孕妇的不良妊娠结局发生率高于正常孕妇,且孕晚期BUA水平升高为不良妊娠结局发生的危险因素,且BUA水平与各因素均有相关性。Objective To analyze the influence of the blood uric acid(BUA)level in the third trimester of pregnancy on the maternal and infant outcome.Methods Seven hundred and seventy pregnant women who gave birth in our hospital from July 2020 to July 2021 were selected as the research objects.According to the level of BUA in the third trimester of pregnancy,they were divided into high uric acid group(≥357μmol/L,n=77)and In the normal group(<357μmol/L,n=693),the adverse pregnancy outcomes of pregnant women and newborns between the two groups were compared.According to whether adverse pregnancy outcomes occurred,the pregnant women were divided into an adverse group(n=253)and a control group(n=517).The general data of the two groups of pregnant women and the clinical data in the third trimester were compared,and the significant factors were logistic.Multivariate analysis identified the risk factors for adverse pregnancy outcomes in pregnant women,and Pearson analyzed the correlation between BUA in the third trimester of pregnancy and various risk factors.Results The incidences of pregnancy complications,hypoalbuminemia,pleural effusion,cardiac insufficiency,liver insufficiency,and renal insufficiency of pregnant women in the hyperuric acid group were higher than those in the normal group.The incidence of fetal distress,asphyxia,low birth weight,and death was higher than that of the normal group,and the difference was significant(P<0.05).Logistic multivariate analysis showed that high systolic blood pressure,blood creatinine,BUA,alanine aminotransferase levels,and low albumin levels were risk factors for adverse pregnancy outcomes in pregnant women(P<0.05).BUA in the third trimester of pregnancy was positively correlated with systolic blood pressure,pre-pregnancy body mass index,serum creatinine,and alanine aminotransferase levels(P<0.05),and negatively correlated with albumin(P<0.05).Conclusion The incidence of adverse pregnancy outcomes in pregnant women with high uric acid is higher than that in normal pregnant wom

关 键 词：血尿酸 孕晚期 母婴结局 危险因素 

分 类 号：R446.11[医药卫生—诊断学]