低分子肝素钠辅助治疗重症急性胰腺炎并发脓毒血症的效果  

Effect of Low Molecular Weight Heparin Sodium in Adjuvant Treatment of Severe Acute Pancreatitis Complicated with Sepsis

作　　者：郭春英 GUO Chunying(Kunshan Second People's Hospital,Kunshan 215300,China)

机构地区：[1]昆山市第二人民医院,江苏昆山215300

出　　处：《中国医药指南》2023年第11期61-64,共4页Guide of China Medicine

摘　　要：目的 研究在重症急性胰腺炎并发脓毒血症患者治疗中运用低分子肝素钠的价值。方法 将2020年5月至2022年5月我院收治的68例重症急性胰腺炎并发脓毒血症患者纳入研究范围,利用随机分配法划分为对照组(接受常规治疗)、观察组(接受常规治疗的同时辅助低分子肝素钠治疗),对比两组患者治疗前后凝血功能指标变化情况,对比两组患者血清WBC、CRP指标变化情况以及急性生理及慢性健康状况评分Ⅱ(APACHE Ⅱ)评分变化情况,对比两组患者治疗前后炎性介质指标变化情况,对比两组患者治疗前后T淋巴细胞亚群变化情况,对比两组治疗有效性。结果 治疗前两组患者各项指标数据之间差异无统计学意义,P>0.05。两组患者接受治疗后各项凝血功能指标均得到明显改善,且观察组整体各项凝血功能指标均明显比对照组更具优势,均低于对照组,P<0.05。两组患者接受治疗后血清WBC、CRP等指标以及APACHE Ⅱ评分均得到改善,且观察组整体血清WBC、CRP指标以及APACHE Ⅱ评分等数据明显比对照组更具优势,均低于对照组,P<0.05。两组患者接受治疗后各项炎性介质指标均得到改善,且观察组各项数据明显比对照组更具优势,均低于对照组,P<0.05。观察组整体治疗总有效率高于对照组,P<0.05,差异有统计学意义。两组患者接受治疗后CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)等数据之间差异无统计学意义,P>0.05。结论 在重症急性胰腺炎并发脓毒血症患者临床治疗中辅助低分子肝素钠治疗,可提升整体治疗效果,帮助患者将凝血功能指标、血清WBC与CRP指标、APACHEⅡ评分、炎性介质指标等控制在合理范围。Objective To discuss the value of low molecular weight heparin sodium in the treatment of severe acute pancreatitis complicated with sepsis.Methods Sixty-eight patients with sepsis complicated by severe acute pancreatitis in the hospital from May 2021 to may 2022 were included in the study.They were randomly divided into control group(received routine treatment)and observation group(received routine treatment and taking low molecular weight heparin sodium as auxiliary treatment).The changes of coagulation function indexes before and after treatment were compared between the two groups,and the serum WBC,CRP index changes and ApacheⅡscore changes,compare the changes of inflammatory mediator indexes before and after treatment between the two groups,compare the changes of T lymphocyte subsets before and after treatment between the two groups,and compare the treatment effectiveness of the two groups.Results There was no significant difference between the two groups before treatment(P>0.05).After treatment,the coagulation function indexes of the two groups were significantly improved,and the overall coagulation function indexes of the observation group were significantly better than those of the control group,both lower than those of the control group,P<0.05.After treatment,the indexes of serum WBC,CRP and ApacheⅡscore in the two groups were improved,and the overall data information of serum WBC,CRP and ApacheⅡscore in the observation group were significantly better than those in the control group,both lower than those in the control group(P<0.05).After the treatment,the indexes of inflammatory mediators in the two groups were improved,and the data information in the observation group was significantly better than that in the control group,both lower than that in the control group(P<0.05).The overall treatment effectiveness data of the observation group was significantly better than that of the control group(P<0.05).There was no significant difference between the two groups in terms of CD_(3)^(+),CD_(4)^(

关 键 词：重症急性胰腺炎 脓毒血症 低分子肝素钠 凝血功能 

分 类 号：R657.5[医药卫生—外科学]