胰岛素样生长因子-1的检测方法及其应用研究进展  

Current Progress on Clinical Application and Quantitative Methods of Insulin-like Growth Factor-1

作　　者：赵旭 金有训 王仙霞 武利庆 刘亚辉 ZHAO Xu;JIN You-xun;WANG Xian-xia;WU Li-qing;LIU Ya-hui(Center for Advanced Measurement Science,National Institute of Metrology,Beijing 100029,China)

机构地区：[1]中国计量科学研究院前沿计量科学中心,北京100029

出　　处：《计量学报》2023年第3期447-456,共10页Acta Metrologica Sinica

基　　金：国家重点研发计划项目(2021YFF0701900);质量技术基础能力建设项目(ANL2202);中国计量科学研究院基本科研业务费项目(AKYZD1907)。

摘　　要：胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1),是一种由70个氨基酸组成的肽类激素。临床研究发现,IGF-1与内分泌疾病、心脑血管疾病、癌症肿瘤、大脑与神经系统相关疾病、皮肤病、肝病等多种疾病都有着十分密切的联系。在新冠肺炎的研究中,IGF-1也扮演了重要角色。因此,可通过准确检测血清中IGF-1含量的变化作为相关疾病的辅助诊断指标之一。目前,临床上针对IGF-1的含量检测方法主要有基于抗原抗体特异性结合的免疫学分析方法和基于质谱技术的分析方法,这些方法具有不同的检测特性,测量准确性也不尽一致。通过对IGF-1的相关研究进展进行综述,总结IGF-1在临床检测应用中的功能作用,讨论其检测方法的特性和应用场景,为进一步提升IGF-1的检测能力提出了建议。Insulin-like growth factor-1(IGF-1)is a peptide hormone composed of 70 amino acids.Clinical studies have found that IGF-1 was closely related to endocrine diseases,cardio-cerebrovascular diseases,cancer tumors,diseases related to brain and nervous system,skin diseases,liver diseases and other diseases.IGF-1 was also found to play an important role in research of COVID-19.Therefore,the changes of serum IGF-1 content can be accurately detected as one of the auxiliary diagnostic indicators of related diseases.At present,the clinical detection methods for IGF-1 mainly include immunological analysis methods based on antigen-antibody specific binding and analysis methods based on mass spectrometry.These methods have different detection characteristics and different measurement accuracy.The relevant research progress of IGF-1 is reviewed,the functional role of IGF-1 in clinical detection and application are summarized,and the characteristics and application scenarios of its detection methods are discussed,the suggestions for further improving the detection ability of IGF-1 are also put forward.

关 键 词：计量学 胰岛素样生长因子-1 生物标志物 定量检测 临床诊断 免疫学分析法 质谱法 

分 类 号：TB99[一般工业技术—计量学]