Cytokine Profiling in Influenza A Virus and Staphylococcal(Co-)Infections  

作　　者：Lea A.Tölken Antje D.Paulikat Fabian Cuypers Sebastian B.Skorka Sven Hammerschmidt Nikolai Siemens 

机构地区：[1]Department of Molecular Genetics and Infection Biology,Interfaculty Institute for Genetics and Functional Genomics,Center for Functional Genomics of Microbes,University of Greifswald,Greifswald,Germany

出　　处：《Infectious Microbes & Diseases》2022年第4期161-167,共7页感染微生物与疾病（英文）

基　　金：funded by the Federal Excellence Initiative of Mecklenburg Western Pomerania and European Social Fund Grant KoInfekt(ESF_14-BM-A55-0001_16 to SH);German Research Foundation(DFG,407176682 to NS).

摘　　要：Influenza A virus and Staphylococcus aureus are common causative agents of pneumonia.Co-infections with these two pathogens frequently occur and are characterized,among others,by higher morbidity and mortality due to hyper-inflammation of the lungs.Here,we aimed to profile systemic and local cytokine composition at early acute stages of pneumonia in amurinemodel.Allmice recovered from single influenza A virus and/or staphylococcal infections.In contrast,co-infections led to a severe clinical outcome.While distinct cytokine patterns were detected in lungs of single-pathogen-infected animals,co-infections combined both virus-and bacteria-driven responses.However,analyses of infected human primarymonocytic cells as well as bronchial epithelial cells did not reflectmurine profiles.Based on infectious dose,mainly bacteria-driven responses were noted.The impact of single cells to cytokine composition of the lungs and translation of murine studies to humans remains uncertain and warrants further studies.

关 键 词：influenza A virus Staphylococcus aureus CO-INFECTION CYTOKINES 

分 类 号：R511.7[医药卫生—内科学]