BPH患者经服用ɑ-受体阻滞剂后仍需手术治疗的多因素logistic回归分析  

Multivariate Logistic Regression Analysis of Patients with BPH Who Still Needed Surgery after Taking α-Receptor Blocker

作　　者：屈颖伟[1] 何文强 郑聪 QU Ying-wei;HE Wen-qiang;ZHENG Cong(The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Henan Province,China)

机构地区：[1]河南中医药大学第一附属医院,河南郑州450000

出　　处：《罕少疾病杂志》2023年第4期57-59,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的回顾性研究服用ɑ-受体阻滞剂治疗后,任然需要接受手术治疗的良性前列腺增生症病例,分析其危险因素。方法回顾性分析2016年1月至2021年7月于我院住院的良性前列腺增生病例共209例,将其分为服药后仍需手术治疗的病例为手术组(n=95),继续口服药物治疗的为药物组(n=114),对患者年龄、连续服药时间、高血压病史、糖尿病史、吸烟史、尿潴留史、饮酒史、BMI、TPV、IPP、I-PSS、PVR、PSA、DWT、Qamx等先行单因素分析,再对有统计学差异的因素,行多因素logistic回归分析。结果经单因素分析发现,BMI、IPP、TPV、I-PSS、PVR、PSA、DWT、Qamx等8项存在统计学差异(P<0.05),此8项因素作多因素Logistic回归分析,显示IPP、PVR、PSA是影响BPH患者服用ɑ-受体阻滞剂后仍需手术治疗的主要危险因素。结论对服用ɑ-受体阻滞剂后仍需接受手术治疗的BPH患者的IPP、PVR、PSA均是其主要危险因素,对预测BPH患者口服α-受体阻滞剂疗效有着重要意义。Objective To retrospectively study the patients with benign prostatic hyperplasia(BPH)who still needed surgical treatment after takingα-receptor blocker,and analyze the risk factors.Methods A total of 209 cases of benign prostatic hyperplasia hospitalized in our hospital from January 2016 to July 2021 were retrospectively analyzed,patients who still needed surgical treatment after taking medicine were divided into the surgical group(n=95)and patients who continued oral drug therapy were divided into the drug group(n=114),patients'age,duration of continuous medication,history of hypertension,history of diabetes,history of smoking,history of urinary retention,history of alcohol consumption,BMI,total prostate volume(TPV),intravesical prostatic protrusion(IPP),international prostate symptom Score(I-PSS),residual urine volume(PVR),prostate specific antigen(PSA),bladder detrusor muscle thickness(DWT),maximum urine flow rate(Qamx)and other factors with statistical differences were first univariate analysis,followed by multivariate Logistic regression analysisand other factors.Results BMI,IPP,TPV,I-PSS,PVR,PSA,DWT and Qamx were statistically different between the two groups(P<0.05).Multivariate Logistic regression analysis showed that IPP,PVR and PSA were the main risk factors for BPH patients who still needed surgical treatment after takingα-receptor blocker.Conclusions IPP,PVR and PSA are the main risk factors for BPH patients who still need surgical treatment after takingα-receptor blocker,which is of great significance for predicting the efficacy of oralɑ-receptor blocker in BPH patients.

关 键 词：Α-受体阻滞剂 前列腺增生 危险因素 

分 类 号：R697.3[医药卫生—泌尿科学]