mDixon-Quant在原发骨质疏松治疗效果评价中应用  

Efficacy of mDixon-Quant in Evaluating the Treatment of the Primary Osteoporosis

作　　者：黄文亮[1] 吴淑芬[1] 周山[1] HUANG Wen-liang;WU Shu-fen;ZHOU Shan(Department of MRI the Second Affiliated Hospital of Luohe Medical College,luohe 462300,Henan Province,China)

机构地区：[1]漯河医学高等专科学校第二附属医院MRI室,河南漯河462300

出　　处：《中国CT和MRI杂志》2023年第4期153-155,共3页Chinese Journal of CT and MRI

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200884);漯河医学高等专科学校科技创新项目(2022-KJYB37)。

摘　　要：目的 探讨mDixon-Quant在原发骨质疏松治疗效果评价中应用价值。方法 原发骨质疏松51例患者接受临床规范骨质疏松治疗(钙剂、维生素D及抗骨质疏松药物),在治疗前、后3、6、9、12个月行双能量X线吸收法(DXA)及mDixon-Quant检查,测量L1-4椎体的骨密度(BMD)、脂肪分数FF_(mDixon)和T_(2)^(*)值,分析治疗前后不同时间点FF_(mDixon)和T_(2)^(*)值、BDM的差异性,以及FF_(mDixon)和、T_(2)^(*)值与骨密度升高率相关性。结果 原发骨质疏松患者治疗前、后3、6、9、12个月骨密度为(0.65±0.058)g/cm^(2)、(0.65±0.069)g/cm^(2)、(0.66±0.049)g/cm^(2)、、(0.68±0.064)g/cm^(2)、(0.79±0.052)g/cm^(2);FF_(mDixon)为(74.32±3.01)%、(73.56±2.98)%、(70.79±2.24)%、(56.32±3.31)%、(54.44±2.81)%;T_(2)值为(18.09±2.01)ms、(17.89±1.99)ms、(13.23±2.21)ms、(12.86±2.07)ms、(11.89±1.89)ms;治疗后12个月BMD、9、12个月FF_(mDixon)、6、9、12个月T_(2)^(*)的值与治疗前比较差异具有统计学意义(P<0.01);设治疗前与治疗后FF_(mDixon)差值(T值)、T_(2)^(*)差值(R值),治疗前后骨密度升高率为(16.92±0.08)%,治疗后T9、T12、R6、R9、R12与腰椎椎体骨密度升高率有正相关性(P<0.05)。结论 原发骨质疏松患者治疗后FF_(mDixon)和T_(2)^(*)值减低,且早期减低幅度与BMD升高率正相关,可作为预测原发骨质疏松治疗效果的理想手段之一。Objective To explore the efficecy of mDixon-Quant in the response of the primary osteoporosis.Method Fifty-one patients with primary osteoporosis received clinical standard treatment,The BMD、FF_(mdixon) and T_(2)^(*)values of L1-4 were measured by DXA and mDixon-Quant before therapy and 3,6,9,12 months after therapy,The BMD、FF_(mdixon) and T_(2)^(*)values were calculated,compared and The FF_(mdixon) and T_(2)^(*)Values were correlated with the rate of rise in BMD.Results The BMD、FF_(mdixon) and T_(2)^(*)values of prior to therapy、3、6、9、12 months after therapy were(0.65±0.058)g/cm^(2)、(0.65±0.069)g/cm^(2)、(0.66±0.049)g/cm^(2)、(0.68±0.064)g/cm^(2)、(0.79±0.052)g/cm^(2);(74.32±3.01)%、(73.56±2.98)%、(70.79±2.24)%、(56.32±3.31)%、(54.44±2.81)%;(18.09±2.01)ms、(17.89±1.99)ms、(13.23±2.21)ms、(12.86±2.07)ms、(11.89±1.89)ms;The BMD Values of 12 months、The FF_(mdixon) Values of 9、12months、The T_(2)^(*)Values of 6、9、12 months showed significant difference with the values of prior to therapy(P<0.01).The rate of rise in BMD was(16.92±0.08)%,The changes(T_(9)、T_(12)、R_(6)、R_(9)、R_(12))in FF_(mdixon) and T_(2)^(*)showed a significand correlation with the rate of rise in BMD(P<0.05).Conclusion The FF_(mdixon) and T_(2)^(*)values of the primary osteoporosis reduced after therapy,the changes of(T_(9)、T_(12)、R_(6)、R_(9)、R_(12))in FF_(mdixon) and T_(2)^(*)showed a correlation with the rate of rise in BMD,which will be an ieal tool to predicte the therapeutic response of the primary osteoporosis.

关 键 词：mDixon-Quant 原发骨质疏松 治疗 骨密度 

分 类 号：R681.5[医药卫生—骨科学]