三维细胞微流控芯片模型的研究现状和在药物毒性评价中的应用进展  

Research status of 3D cell microfluidic chip model and its application in drug toxicity evaluation

作　　者：朱丽颖 张丹丹[1,2] 杜宏英 于明星 朱彦 ZHU Liying;ZHANG Dandan;DU Hongying;YU Mingxing;ZHU Yan(State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Research and Development Center of Chinese Medicine,Tianjin International Joint Academy of Biomedicine,Tianjin 300457,China)

机构地区：[1]天津中医药大学组分中药国家重点实验室,天津301617 [2]天津国际生物医药联合研究院中药新药研发中心,天津300457

出　　处：《天津中医药大学学报》2023年第2期257-263,共7页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：国家科技重大专项(2018ZX01031301);国家重点研发计划项目(2018YFC1704502);国家自然科学基金资助项目(81873037)。

摘　　要：目前用于临床前药物筛选和评价的传统细胞培养和动物模型存在不同程度的缺陷。三维细胞微流控芯片模型作为一种新型的体外研究模型,能够高度模拟人体组织的生理结构、功能,组织所处的生化和力学微环境,经长期培养保持组织功能稳定,因此在构建生理病理模型、药物筛选及再生医学等方面具有广阔前景。文章综述了三维细胞微流控芯片模型的研究进展,以药物毒性评价为重点讨论了其优势、可行性、中药应用实例和存在问题,并针对中药传承创新研究的特点展望了三维细胞微流控芯片模型的价值和广阔应用前景。At present,the traditional cell culture and animal models used for pre-clinical drug screening and evaluation have different degrees of defects.Three-dimensional cell microfluidic chip model as a new research model in vitro,can simulate high tissue physiological structure,function,structure of biochemical and mechanical environment,maintain tissue function is stable,long-term training in physiological and pathological model was constructed,drug screening and regenerative medicine has broad prospects.In this paper,the research progress of 3D cell microfluidic chip model was reviewed.The advantages,feasibility,application cases and existing problems of 3D cell microfluidic chip model were discussed with drug toxicity evaluation as the focus,and the great value and broad application prospects of 3D cell microfluidic chip model were prospected according to the characteristics of traditional Chinese medicine inheritance and innovation research.

关 键 词：3D细胞 微流控芯片 药物毒性评价 生物打印 类器官 

分 类 号：R282.7[医药卫生—中药学]