基于纳米材料的微针阵列技术及其应用  

Nanomaterial-based Microneedle Arrays Technology and Its Application:a Review

作　　者：刘勇 刘哲 高广志 李志勇 马凤森[1] LIU Yong;LIU Zhe;GAO Guangzhi;LI Zhiyong;MA Fengsen(Laboratory of Biologics and Biomaterials,College of Pharmacy,Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]浙江工业大学药学院生物制剂与材料实验室,杭州310014

出　　处：《材料导报》2023年第8期213-222,共10页Materials Reports

基　　金：浙江省重点科技创新团队计划资助项目(2013TD15)。

摘　　要：近年来,微针因具有无痛微创、安全高效等优点,受到了众多研究者的关注,已被广泛应用于透皮给药、医学美容和生物诊断等领域。但传统微针尤其是由聚合物材料直接制备的微针普遍存在机械强度较低、药物释放模式单一、生物传感性能差、可实现功能较简单等问题。由于纳米粒具有独特的机械强度、小尺寸特性以及光电效应,将纳米技术与微针巧妙结合可有效改善上述问题。本文综述了用于微针的纳米粒,包括无机(金属、无机非金属)纳米粒、有机(高分子、脂质)纳米粒和药物纳米颗粒(纳米晶体药物、病毒样颗粒),并介绍了纳米粒在增加力学性能、协同改善药物释放和免疫增强等方面的作用,讨论了该领域亟待解决的问题和展望了未来的研究方向。In recent years,microneedles have received a lot of attention from researchers because of its advantages of being painless and minimally invasive,safe and efficient.Microneedles have been widely used in the fields of transdermal drug delivery,medical aesthetics and biological diagnosis.However,traditional microneedles,especially those prepared directly from polymer materials,generally have problems such as low mechanical strength,single drug release mode,poor biological sensing performance and simple functions.The clever combination of nanotechnology and microneedles can effectively improve the above problems,due to the unique nano-size,mechanical strength and photoelectric effects of nanoparticles.This paper reviews nanoparticles for microneedles,including inorganic nanoparticles(metal,inorganic non-metal),organic nanoparticles(polymer,lipid)and drug nanoparticles(nanocrystalline drugs,virus-like particles),and describes the role of nanoparticles in increasing mechanical property,synergistic improvement of drug release and immune enhancement are introduced.Finally,the urgent problems need to be solved in this field and the future research directions are discussed.

关 键 词：微针 纳米粒 力学性能 缓控释 免疫增强 

分 类 号：R94[医药卫生—药剂学]