氡与肺癌关系的研究进展  

Research progress between radon and lung cancer

作　　者：张有奇 邹昕宇 吴建军[1,2] 杨帆 ZHANG You-qi;ZOU Xin-yu;WU Jian-jun;YANG Fan(Key Laboratory of Myocardial Ischemia,Ministry of Education,Harbin 150001,China;Department of Cardiology,The Second Affiliated Hospital of Harbin Medical University)

机构地区：[1]心肌缺血教育部重点实验室,哈尔滨150001 [2]哈尔滨医科大学附属第二医院心血管内科

出　　处：《环境卫生学杂志》2023年第3期224-228,共5页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：国家自然科学基金青年科学基金资助项目(81901853)。

摘　　要：肺癌具有极高的侵袭和转移风险,对人类健康和生命存在重大威胁。在不吸烟的人群中,氡暴露是导致肺癌的首要原因。截至目前,不同的荟萃分析结果发现氡暴露与肺癌之间存在剂量反应关系。由于样本量、所用检测器的数量和类型、性别纳入和吸烟状况不同,这些研究存在很大的异质性。已经明确氡可以导致DNA损伤和基因组高度不稳定性,但其在肺癌中的确切致癌机制尚不清楚。本文从氡致肺癌的流行病学、机理、血清学变化和筛查预防四个方面对肺癌和氡之间的联系进行综述,为氡和肺癌的研究及防治提供参考。Lung cancer is a malignant tumor originating from the bronchial mucosa or glands of the lung,with a high risk of invasion and metastasis.Lung cancer is one of the most malignant tumors to human health and life.Radon exposure is the leading cause of lung cancer in non-smokers.To date,different meta-analysis studies have demonstrated a dose-response relationship between radon exposure and lung cancer.These studies are very heterogeneous due to different sample size,number and type of detectors used,gender inclusion and smoking status.It is well established that radon can cause DNA damage and high genomic instability,but its exact oncogenic mechanism in lung cancer remains unclear.Our review describes the association between lung cancer and radon from the epidemiology,the mechanism,serological changes and screening prevention of radon-induced lung cancer,to improve the public′s understanding of radon and lung cancer,and provides new insights for the research and prevention of radon and lung cancer.

关 键 词：肺癌 氡暴露 基因组 血清标志物 

分 类 号：R122[医药卫生—环境卫生学]