正交试验设计结合熵权TOPSIS优选阿胶珠炮制工艺  

Optimization of the Processing Technology of Beads of Asini Corii Colla by Orthogonal Experimental Design and Entropy Weight-TOPSIS Method

作　　者：程钰洁 文珊 邓怡芳 刘权震 林荣楷 李玲 魏梅 CHENG Yu-jie;WEN Shan;DENG Yi-fang;LIU Quan-zhen;LIN Rong-kai;LI Ling;WEI Mei(Guangdong Yifang Pharmaceutical Co.,Ltd./Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Formula Granule,Foshan 528244,China)

机构地区：[1]广东一方制药有限公司/广东省中药配方颗粒企业重点实验室,广东佛山528244

出　　处：《中国现代中药》2023年第2期361-368,共8页Modern Chinese Medicine

基　　金：广东省基础与应用基础研究基金项目(2020B1515120033)。

摘　　要：目的:优选阿胶珠的炮制工艺。方法:采用L9(34)正交试验设计,以外观性状、水分、总灰分、特征多肽及氨基酸含量为指标,以炮制时间、炮制温度、每锅辅料用量为考察因素,结合直观分析、方差分析和熵权逼近理想解排序法(TOPSIS)对正交试验结果进行评价,优选阿胶珠炮制工艺,并进行炮制工艺验证。结果:优选的阿胶珠炮制工艺参数为炮制时间5 min、炮制温度190℃、蛤粉-阿胶为30∶1;验证实验中3批样品各指标的RSD为2.09%~4.91%。结论:优选的阿胶珠炮制工艺合理可行,可为阿胶珠工业化炮制生产提供参考。Objective:To optimize the processing technology of beads of Asini Corii Colla.Methods:With the traits,moisture,total ash,and the content of characteristic peptides and amino acid as indicators and the processing time,processing temperature,and dosage of adjuvant materials per pot as the investigation factors,using L9(34)orthogonal test design,the orthogonal experimental results were evaluated by intuitive analysis,variance analysis,and entropy weight-technique for order of preference by similarity to ideal solution method(TOPSIS),to optimize the processing technology of beads of Asini Corii Colla and verify the processing technology.Results:The optimized processing conditions of beads of Asini Corii Colla were as follows:processing time of 5 min,processing temperature of 190℃,and clam meal-Asini Corii Colla of 30:1.The RSDs of indicators in three batches of experimental samples were in the range of 2.09%-4.91%.Conclusion:The optimized processing technology is reasonable,which can provide references for the industrial production of beads of Asini Corii Colla.

关 键 词：阿胶珠 炮制工艺 正交试验 熵权逼近理想解排序法 

分 类 号：R283[医药卫生—中药学]