兽用抗菌药物PK/PD同步模型研究进展  

Advance in Pharmacokinetics/Pharmacodynamics Models of Veterinary Antimicrobial Drugs

作　　者：魏海涛 方秋华 杨伟聪 张炳顺 刘铄佳 WEI Haitao;FANG Qiuhua;YANG Weicong;ZHANG Bingshun;LIU Shuojia(Jieyang Runda Casing Co.,Ltd.,Jieyang Guangdong 522000;Guangdong Best Biotechnology Research Institute Co.,Ltd.,Jieyang Guangdong 522000)

机构地区：[1]揭阳市润达肠衣有限公司,广东揭阳522000 [2]广东百试特生物技术研究院有限公司,广东揭阳522000

出　　处：《广东畜牧兽医科技》2023年第2期24-29,共6页Guangdong Journal of Animal and Veterinary Science

基　　金：揭阳市科技计划项目“高新区研发平台(新型研发机构)建设”(2018dzx001)。

摘　　要：近年来关于兽用抗菌药物的药代动力学/药效学(Pharmacokinetics/Pharmacodynamics,PK/PD)同步模型的研究取得较大进展。了解PK/PD同步模型的基本概念,利用PK/PD同步模型优化给药方案,可以增强药物的抗菌效果,减少耐药性的发生。该文介绍了PK/PD同步模型的研究方法和应用进展,以及PK/PD同步模型在兽药领域面临的挑战和应用前景,以期提高对兽药PK/PD同步模型及其未来发展趋势的认识,为兽用抗菌药物PK/PD同步模型研究开展提供一定理论基础。The remarkable progress of veterinary antimicrobial drugs(AMDs)pharmacokinetics/pharmacodynamics(PK/PD)models has been made in recent years.Understanding the basic concept of PK/PD model and optimizing the dosage regimen can improve the antibacterial effect of AMDs and reduce the occurrence of drug resistance.This paper introduces the research methods and progress of PK/PD model,as well as the challenges and application prospects of PK/PD model in veterinary AMDs and its future development trend,and provide a theoretical basis for the research of PK/PD model for veterinary AMDs.

关 键 词：PK/PD同步模型 抗菌药物 给药方案 细菌耐药性 

分 类 号：S859.7[农业科学—临床兽医学]