负载石榴皮提取物的聚乙烯醇基水凝胶伤口敷料的制备与表征  

Preparation of Polyvinyl Alcohol Hydrogel Wound Dressing Loaded With Pomegranate Peel Extract

作　　者：赵中楠 张兴群 翟志毫[1] 何明宇 夏鑫 王颖[1] ZHAO Zhongnan;ZHANG Xingqun;ZHAI Zhihao;HE Mingyu;XIA Xin;WANG Ying(College of Textile and Clothing,Xinjiang University,Urumqi 830046,China;College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China;College of Life Science and Technology,Xinjiang University,Urumqi 830046,China)

机构地区：[1]新疆大学纺织与服装学院,乌鲁木齐830046 [2]东华大学化学化工与生物工程学院,上海201620 [3]新疆大学生命科学与技术学院,乌鲁木齐830046

出　　处：《功能高分子学报》2023年第2期136-145,共10页Journal of Functional Polymers

基　　金：国家自然科学基金项目(51863020);新疆维吾尔自治区自然科学基金面上项目(2021D01C059);新疆维吾尔自治区天池博士计划项目(042312060)。

摘　　要：以聚乙烯醇(PVA)和羧甲基纤维素钠(Na-CMC)为原料,以丙三醇(GL)水溶液为溶剂,利用循环冻融法制备一种负载石榴皮提取物(PPE)的水凝胶。对水凝胶的化学结构、透光率、抗干燥性、溶胀性、拉伸性能、体外药物释放、抗氧化性及抗菌性进行了研究。结果表明,制备的水凝胶具备较好的抗干燥性,室温下放置72 h仍能保持完整。PPE的加入使水凝胶的透光率降低,溶胀性、拉伸性提高,同时使水凝胶具备良好的抗菌性和抗氧化性。经测试水凝胶中PPE的累计释放率最高可达(67.47±3.75)%,对金黄色葡萄球菌、大肠杆菌均具有较好的抑菌性,抑菌圈最大分别为(18.78±0.26)mm、(15.11±0.23)mm,对1,1-二苯基-2-苦肼基(DPPH)的清除率最高可达(93.65±2.27)%。In order to develop a wound dressing loaded with pomegranate peel extract(PPE),the hydrogel was prepared by cyclic freeze-thaw method using polyvinyl alcohol(PVA)and sodium carboxymethyl cellulose(Na-CMC)as raw materials,glycerol(GL)aqueous solution was used as the solvent.Subsequently,the chemical structure of hydrogels was analyzed by FT-IR.In addition,the transmittance,anti-drying,swelling,tensile properties,in vitro drug release,anti-oxidation and antibacterial properties of hydrogels were also studied.Results showed that the prepared hydrogels had good drying resistance and could remain intact at room temperature for 72 h.The addition of PPE reduced the light transmittance of the hydrogel,improved the swelling and tensile property of the hydrogel,and made the hydrogel have good antibacterial and antioxidant properties.The cumulative release of PPE in the hydrogel was(67.47±3.75)%,which showed good antibacterial activity against Staphylococcus aureus and Escherichia coli.The inhibition zones were(18.78±0.26)mm and(15.11±0.23)mm,respectively.The highest scavenging rate to 1,1-diphenyl-2-picrylhydrazyl(DPPH)was(93.65±2.27)%.Therefore,the hydrogel loaded with PPE prepared in this study has the potential as a wound dressing.

关 键 词：石榴皮提取物 聚乙烯醇 羧甲基纤维素钠 水凝胶 伤口敷料 

分 类 号：R318.08[医药卫生—生物医学工程] TB34[医药卫生—基础医学]