眼表菌群与慢性全身性疾病关系的研究进展  

Research advances in relationship between ocular surface microflora and chronic systemic diseases

作　　者：张婷 杨庭树[2] 向圣锦 曹文斋[4] ZHANG Ting;YANG Tingshu;XIANG Shengjin;CAO Wenzhai(Department of Scientific Research Center,Sichuan Vocational College of Health and Rehabilitation,Zigong 643000,Sichuan Province,China;Department of Cardiology,Chinese PLA General Hospital,Beijing 100853,China;Department of TCM Ophthalmology,Wenzhou Medical University Affiliated Optometry Hospital,Wenzhou 325027,Zhejiang Province,China;Department of Ophthalmology,Zigong First People's Hospital,Zigong 643000,Sichuan Province,China)

机构地区：[1]四川卫生康复职业学院科研中心,四川自贡643000 [2]解放军总医院心内科,北京100853 [3]温州医科大学附属眼视光医院中医眼科,浙江温州325027 [4]自贡市第一人民医院眼科,四川自贡643000

出　　处：《解放军医学院学报》2023年第2期177-181,共5页Academic Journal of Chinese PLA Medical School

基　　金：四川省科技厅项目(2018JY0583);浙江省卫健委课题(2022ZX013);自贡市医学科学院科研课题(2021ZCYKY05)。

摘　　要：正常情况下眼表菌群与人体和平共生,在眼部的防御体系和机体免疫调节中起着重要作用。当机体状态改变或免疫功能异常时,这种互利共生的平衡可能被打破,眼表菌群多样性和核心组成发生改变,从而影响眼表稳态,导致眼部疾病的出现。微生物虽存在于眼表,但其对机体的免疫功能和作用路径仍值得深入研究。本文将着重阐述眼表菌群的影响因素,眼表菌群与慢性全身性疾病(如代谢性疾病、感染性疾病、退行性疾病和肿瘤等)相关研究进展,以期进一步拓宽眼表微生物组与关联疾病的研究范围,为眼表菌群研究开启新思路。Normally,ocular surface microbiota coexists peacefully with human body,which plays an important role in the defense system of the ocular surface system and the immune regulation of the body.When the body state changes or the immune function is abnormal,the balance of mutualism may be broken,and the diversity and composition of ocular surface bacteria may change,thus affecting ocular surface homeostasis and immune function,leading to the occurrence of eye diseases.Current studies have found that ocular surface bacterial imbalance is closely related to ocular surface and ocular diseases.However,although microbiota exists on the ocular surface,its immune mechanism and action path remain to be further explored.This paper focuses on the current research progress on chronic systemic diseases and ocular microbiome,in order to further expand the research scope on ocular microbiome and associated diseases,and open new ideas for the study of ocular microbiome.

关 键 词：眼表菌群 眼表微生物 微生物群落 眼表 慢性全身性疾病 

分 类 号：R593.2[医药卫生—内科学]