木犀草素的生理作用及制剂研究进展  

Research progress on physiological action and preparations of luteolin

作　　者：詹鑫 徐帆 祝钧[1,2] 何一凡[1,2] 裴晓静 Xin Zhan;Fan Xu;Jun Zhu;Yifan He;Xiaojing Pei(Institute of Cosmetic Regulatory Science,Beijing Technology&Business University,Beijing 100048,China;College of Chemistry and Materials Engineering,Beijing Technology&Business University,Beijing 100048,China)

机构地区：[1]北京工商大学化妆品监管科学研究基地,北京100048 [2]北京工商大学化学与材料工程学院,北京100048

出　　处：《日用化学工业（中英文）》2023年第4期437-444,共8页China Surfactant Detergent & Cosmetics

基　　金：国家重点研发计划“科技助力经济2020”重点专项(2020YFF0426290)。

摘　　要：木犀草素作为一种天然的黄酮类化合物,是一种可用于化妆品的功效原料,在皮肤上具有抗氧化、抗炎、延缓衰老以及美白作用,但存在溶解性差以及生物利用度低的问题,导致其在化妆品中的应用受到了限制。通过固体分散体、环糊精包合物、磷脂复合物、固体脂质纳米粒、纳米结构脂质体、纳米乳、聚合物胶束等制剂技术可以提高其溶解度和生物利用度,进而发挥良好作用。综述了木犀草素在皮肤上的抗氧化、抗炎、延缓衰老和美白作用通路,以及木犀草素应用于不同制剂技术的研究进展,用以改善木犀草素的溶解度和生物利用度差的问题,同时为进一步促进木犀草素制剂研究及化妆品产品应用提供参考。Luteolin is a natural flavonoid compound and can be used as cosmetic raw material.Studies have shown that luteolin can provide hydrogen atoms to react with free radicals to generate stable compounds and enhance the activity of antioxidant enzymes to achieve antioxidant effects.It can also inhibit the expression of inflammatory cytokines and inflammatory mediators by affecting multiple inflammatory signaling pathways.It can also delay aging by inhibiting kinases that affect skin aging and whiten the skin by inhibiting enzymes involved in the synthesis of melanin.However,the solubility and bioavailability of luteolin are poor since it is only slightly soluble both in hot water and in cold water.Its solubility and bioavailability can be improved by preparation technologies such as solid dispersion,cyclodextrin inclusion,phospholipid complexation,formation of solid lipid nanoparticles,nanostructured liposomes,nanomilk and polymer micelles,etc.However,some preparation technologies have the problems of high cost,short shelf life,instability,etc.,and further research on the action mechanism of luteolin and related preparations is needed.The physiological action mechanisms of luteolin on the skin,as well as the research progress of its various preparation techniques,were reviewed,which could provide a reference for further preparation research and cosmetic product application.

关 键 词：木犀草素 生理作用 化妆品 制剂 

分 类 号：TQ658[化学工程—精细化工]