子痫前期患者血浆β-HCG、PLGF、E_(2)水平变化及临床意义  

Changes in plasma levels of β-HCG,PLGF,and E_(2) in preeclamptic patients and their clinical significance

作　　者：李晶晶 吕淑敏 Li Jingjing;Lyu Shumin(Department of Medical Laboratory,Obstetrics and Gynecology Hospital of Kaifeng,Kaifeng Henan 475000,China)

机构地区：[1]河南省开封市妇产医院医学检验科,河南开封475000

出　　处：《保健医学研究与实践》2023年第2期29-32,共4页Health Medicine Research and Practice

基　　金：河南省医学科技攻关计划项目(SBGJ202102097)。

摘　　要：目的 探讨子痫前期(PE)患者血浆人绒毛膜促性腺激素(β-HCG)、胎盘生长因子(PLGF)、雌二醇(E_(2))的水平变化及临床价值。方法 选择2020年9月—2022年5月开封市妇产医院收治的112例PE患者,将61例重度PE患者作为重度组,其他51例患者作为轻度组,选择同时期内于医院住院待产的正常孕妇100例作为对照组。比较各组研究对象血浆β-HCG、PLGF、E_(2)水平,并评估几个指标对重度PE的预测价值。结果 3组孕妇血浆β-HCG、PLGF、E_(2)水平比较,差异均有统计学意义(P<0.05);重度组和轻度组孕妇血浆β-HCG水平均高于对照组,PLGF和E_(2)水平均低于对照组,差异均有统计学意义(P<0.05);重度组孕妇血浆β-HCG水平高于轻度组,PLGF和E_(2)水平低于轻度组,差异均有统计学意义(P<0.05)。Logistic多因素回归分析结果显示,孕妇血浆β-HCG、PLGF、E_(2)水平异常是重度PE的独立危险因素(P<0.05)。受试者工作特征曲线(ROC)分析结果显示,β-HCG、PLGF、E_(2)联合检测预测重度PE的ROC曲线下面积(AUC)、敏感性和特异性分别为0.879、85.14%和88.91%,均高于单项指标检测。结论PE患者血浆β-HCG、PLGF、E_(2)水平存在明显改变,指标水平高低与PE患者的病情严重程度密切相关,联合检测能帮助临床快速识别重度PE患者,具有一定临床价值。Objective This paper aims to investigate the changes in plasma levels ofβ-HCG,PLGF,and E_(2) in preeclamptic(PE)patients and their clinical significance.Methods A total of 112 PE patients admitted to the Obstetrics and Gynecology Hospital of Kaifeng from September 2020 to May 2022 were selected,with 61 severe PE patients as the severe group and 51 other patients as the mild group.A control group of 100 normal pregnant women admitted to the hospital for delivery during the same period was selected.The plasma levels ofβ-HCG,PLGF,and E_(2) were compared among the groups,and the predictive value of several indicators for severe PE was evaluated.Results The differences in plasma levels ofβ-HCG,PLGF,and E_(2) among the three groups of pregnant women were statistically significant(P<0.05).The plasma levels ofβ-HCG in the severe and mild groups were significantly higher than those in the control group,while the levels of PLGF and E_(2) were significantly lower than those in the control group(P<0.05).The plasma levels ofβ-HCG in the severe group were significantly higher than those in the mild group,while the levels of PLGF and E_(2) were significantly lower than those in the mild group(P<0.05).The multivariate logistic regression analysis showed that abnormal levels ofβ-HCG,PLGF,and E_(2) in pregnant women were independent risk factors for severe PE(P<0.05).The results of receiver operating characteristic(ROC)analysis showed that the area under the ROC curve(AUC),sensitivity,and specificity of the combined detection ofβ-HCG,PLGF,and E_(2) for predicting severe PE were 0.879,85.14%,and 88.91%,respectively,which were higher than those of single indicators.Conclusion Significant changes are presented in plasma levels ofβ-HCG,PLGF,and E_(2) in PE patients,and the levels of these indicators are closely related to the severity of the disease.Combined detection can help clinicians quickly identify severe PE patients and has certain clinical significance.

关 键 词：子痫前期 胎盘生长因子 人绒毛膜促性腺激素 雌二醇 诊断价值 

分 类 号：R714.24[医药卫生—妇产科学]