IL-6、NE-CPD联合皮肤温度变化对膝关节置换术后早期感染的预测价值  

Predictive value of IL-6,NE-CPD combined with skin temperature changes for early infection after knee arthroplasty

作　　者：李格[1] 崔中锋 Li Ge;Cui Zhongfeng(Department of Blood Transfusion,the Sixth People's Hospital of Zhengzhou,Zhengzhou 450000,China;Department of Clinical Laboratory,the Sixth People's Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]河南省郑州市第六人民医院输血科,郑州450000 [2]河南省郑州市第六人民医院检验科,郑州450000

出　　处：《保健医学研究与实践》2023年第2期33-38,共6页Health Medicine Research and Practice

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210691)。

摘　　要：目的探讨持续性检测白细胞介素-6(IL-6)、中性粒细胞群落参数(NE-CPD)联合皮肤温度变化对膝关节置换术后早期感染的预测价值。方法选取2020年3月—2022年3月于河南省郑州市第六人民医院接受人工膝关节置换手术治疗的85例老年患者,根据术后3个月内是否发生膝关节假体感染分为感染组(n=7)与未感染组(n=78)。比较2组患者术前、术后1 d、术后7 d、术后1个月、术后3个月血清IL-6、血液NE-CPD及膝关节手术部位周围皮肤温度。结果2组患者术前及术后1 d血清IL-6水平比较,差异均无统计学意义(P>0.05);未感染组患者术后7 d、术后1个月、术后3个月血清IL-6水平低于感染组,差异均有统计学意义(P<0.05)。2组患者术前NE-CPD相关参数比较,差异均无统计学意义(P>0.05)。2组患者术后1 d的体积均值(MN-V-NE)均高于术前,术后7 d的MN-V-NE均低于术后1 d,术后1个月MN-V-NE均低于术后7 d,差异均有统计学意义(P<0.05);感染组患者术后3个月MN-V-NE高于术后1个月,差异有统计学意义(P<0.05);未感染组患者术后1 d、7 d、1个月、3个月MN-V-NE均低于感染组,差异均有统计学意义(P<0.05)。2组患者术前及术后不同时间点组间及组内传导性均值(MN-C-NE)比较,差异均无统计学意义(P>0.05)。感染组患者术后3个月中位角光散射均值(MN-MALS-NE)低于术前,差异有统计学意义(P<0.05);感染组患者术后1个月、3个月MN-MALS-NE低于未感染组,差异均有统计学意义(P<0.05)。感染组患者术后3个月高中位角光散射均值(MN-UMALS-NE)低于术前及未感染组,差异均有统计学意义(P<0.05)。感染组患者术后3个月低中位角光散射均值(MN-LMALS-NE)低于未感染组,差异有统计学意义(P<0.05)。感染组患者术后1个月、3个月轴向光吸收均值(MN-AL2-NE)低于未感染组,差异均有统计学意义(P<0.05)。2组患者术前及术后不同时间点手术部位周围皮肤温度比较,差异有统计学意�Objective To investigate the predictive value of continuous detection of interleukin-6(IL-6)and neutrophil cell population data(NE-CPD)parameters combined with skin temperature changes for early infection after knee arthroplasty.Methods Eighty-five elderly patients who underwent total knee arthroplasty in the Sixth People's Hospital of Zhengzhou from March 2020 to March 2022 were selected and assigned to the infected(n=7)and uninfected groups(n=78)following the presence or absence of knee prosthesis infection 3 months after surgery.Serum IL-6,blood NE-CPD-related parameters,and skin temperature around the knee joint surgical site were compared between the two groups before surgery,1 d,7 d,1 month,and 3 months after surgery.Results There was no significant difference in serum IL-6 levels before the operation and 1 d after the operation between the two groups(P>0.05);the serum IL-6 levels at 7 d,1 month,and 3 months after the operation in the uninfected group were significantly lower than those in the infected group(P<0.05).There were no significant differences in NE-CPD-related parameters between the 2 groups before surgery(P>0.05).mean volumec(MNV-NE)at 1 d after the operation in both groups was significantly higher than that before the operation,MN-V-NE at 7 d after the operation was lower than that at 1 d after the operation,and MN-V-NE at 1 month after the operation was lower than that at 7 d after the operation,with satistical significance(P<0.05).MN-V-NE at 3 months after operation in the infected group was higher than that at 1 month after the operation,and the differences were statistically significant(P<0.05).MNV-NE at 1 d,7 d,1 month,and 3 months after operation in the uninfected group was lower than that in the infected group,and the differences were statistically significant(P<0.05).There were no significant differences in mean conductivity(MNC-NE)between and within groups at different time points before and after surgery between the 2 groups(P>0.05).mean of median angle light scattering(MN-MALS-NE)at

关 键 词：IL-6 NE-CPD 皮肤温度 膝关节置换术 假体感染 预测价值 

分 类 号：R446.11[医药卫生—诊断学]