白介素-31参与瘙痒的研究进展  

Research Progress of IL-31 in Itch

作　　者：李康良 邱彩雄 何爽 黄春华 伍冠一 LI Kangliang;QIU Caixiong;HE Shuang;HUANG Chunhua;WU Guanyi(College of Basic Medicine,Guangxi University of Chinese Medicine,Nanning Guangxi 530299,China;College of Pharmacology,Guangxi University of Chinese Medicine,Nanning Guangxi 530299,China)

机构地区：[1]广西中医药大学基础医学院,广西南宁530299 [2]广西中医药大学药学院,广西南宁530299

出　　处：《广西师范大学学报（自然科学版）》2023年第2期27-35,共9页Journal of Guangxi Normal University:Natural Science Edition

基　　金：国家自然科学基金(81860740,82060768);广西自然科学基金(2020JJA140311)。

摘　　要：瘙痒是很多皮肤疾病的常见临床症状,包括特应性皮炎、结节性痒疹、银屑病、慢性荨麻疹等。最近的研究表明,白介素-31在皮肤疾病的瘙痒中扮演重要角色。白介素-31可由CD4+辅助T细胞、肥大细胞、角化细胞、巨噬细胞、树突状细胞等合成与释放,通过激活白介素-31异二聚体受体(IL-31受体A和抑瘤素受体M)产生痒觉相关信号。尽管研究发现白介素-31可通过直接或间接的作用向神经中枢传递痒觉信号,但是它的致痒机制尚不完全清楚。本文就白介素-31的基因、受体、来源以及在瘙痒相关疾病中的作用展开综述。Itch is a normal symptom in many skin diseases such as atopic dermatitis,prurigo nodularis,psoriasis,and chronic urticaria.More and more data show that interleukin-31(IL-31)plays an important role in itch.IL-31 is composed and released from CD4+help T cell,mast cells,keratinocytes,macrophages,and dendritic cells.By activating interleukin-31 heterodimer receptors(IL-31 receptor A and tumor suppressor M receptor),itch related signals are generated.Although it has been found that IL-31 can transmit itch signals to the central nerve system directly or indirectly,mechanism of itch is not fully understood.This review summarizes the current knowledge on IL-31’s gene,source,receptor,and the effect of IL-31 in pruritic diseases.

关 键 词：白介素-31 瘙痒 皮肤疾病 白介素-31受体 角化细胞 肥大细胞 

分 类 号：R751[医药卫生—皮肤病学与性病学] Q432[医药卫生—临床医学]