地蚕的化学成分研究  

Chemical Constituents of Stachys geobombycis C.Y.Wu

作　　者：闫梦麒 韦易伸 黄婉仪 王力生 覃江克[2] 周先丽[3] 梁成钦[1] YAN Mengqi;WEI Yishen;HUANG Wanyi;WANG Lisheng;QIN Jiangke;ZHOU Xianli;LIANG Chengqin(College of Pharmacy,Guilin Medical University,Guilin Guangxi 541199,China;State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Guangxi Normal University),Guilin Guangxi 541004,China;College of Biotechnology,Guilin Medical University,Guilin Guangxi 541199,China)

机构地区：[1]桂林医学院药学院,广西桂林541199 [2]省部共建药用资源化学与药物分子工程国家重点实验室(广西师范大学),广西桂林541004 [3]桂林医学院生物技术学院,广西桂林541199

出　　处：《广西师范大学学报（自然科学版）》2023年第2期124-130,共7页Journal of Guangxi Normal University:Natural Science Edition

基　　金：国家自然科学基金(81860621);广西自然科学基金(2018GXNSFBA281032)。

摘　　要：利用硅胶柱色谱、Sephdex LH-20柱色谱以及半制备HPLC等方法,从地蚕中分离得到14个化合物,通过现代波谱技术鉴定其结构,分别为:酪醇(1)、烟酰胺(2)、2,2-bis[4-(2,3-dihydroxypropoxy)phenyl]propane(3)、香草酸(4)、丁香酸(5)、5-(α-D-吡喃半乳糖基-(1→6)-α-D-吡喃半乳糖基氧甲基)-2-呋喃甲醛(6)、8-O-acetyl harpagide(7)、地黄苷(8)、邻苯二甲酸二丁酯(9)、tatarine C-4′-O-β-D-glucopyranoside(10)、bis(2-ethylhexyl)benzene-1,2-dicarboxylate(11)、5-(α-D-半乳吡喃氧基甲基)-2-呋喃甲醛(12)、5-羟甲基呋喃甲醛(13)和焦谷氨酸正丁酯(14)。其中化合物1~4和6~14均为首次从该植物中分离得到。The compounds were isolated and purified from Stachys geobombycis by column chromatography with silica gel,Sephadex LH-20 and semi-preparative HPLC,and their structures were identified by modern spectral data.Fourteen compounds were isolated and identified as tyrosol(1),nicotinamide(2),2,2-bis[4-(2,3-dihydroxypropoxy)phenyl]propane(3),vanillic acid(4),syringate(5),5-(α-D-galactopyranosyl-(1-6)-α-D-galactopyranosyloxymeth-yl)-2-furancarboxaldehyde(6),8-O-acetyl harpagide(7),martynoside(8),dibutyl phthalate(9),tatarine C-4′-O-β-D-glucopyranoside(10),bis(2-ethylhexyl)benzene-1,2-dicarboxylate(11),(5-(α-D-galactopyranosyloxymethyl)-2-furancarboxaldehyde)(12),5-hydroxymethyl-furaldehyde(13)and n-butyl pyroglutamate(14).Among them,compounds 1-4 and 6-14 were isolated from the S.geobombycis for the first time.

关 键 词：地蚕 分离纯化 结构鉴定 化学成分 

分 类 号：R284.1[医药卫生—中药学]