铁死亡机制与脑缺血再灌注损伤及中医药干预进展  

Progress of the Traditional Chinese Medicine in the Regulation of Ferroptosis in Cerebral Ischemia-Reperfusion Injury

作　　者：潘单依 刘旺华[1,2,3] PAN Dan-Yi;LIU Wang-Hua(The Domestic First-class Discipline Construction Project of Chinese Medicine,Hunan University of Chinese Medicine;Provincial Key Laboratory of TCM Diagnostics;Key Laboratory of TCM Heart and Lung Syndrome Differentiation&Medicated Diet and Dietotherapy,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学中医学国内一流建设学科 [2]湖南中医药大学中医诊断学湖南省重点实验室 [3]湖南中医药大学中医心肺病证辨证与药膳食疗重点研究室,长沙410208

出　　处：《生理科学进展》2023年第2期90-96,共7页Progress in Physiological Sciences

基　　金：国家自然科学基金(No.81473567);湖南省中医药科研计划课题项目(No.202008、No.2021013);湖南省高校创新平台开放基金项目(No.20K097);湖南中医药大学研究生创新课题项目(No.2022CX52)资助课题。

摘　　要：缺血性中风是一种由大脑局部血流中断引起的脑血管疾病。缺血侧脑组织的快速有效再生是治疗缺血性中风的关键措施,但在再生和复流过程中存在再灌注损伤的风险。脑缺血再灌注损伤(cerebral ischemia-reperfusion injury,CIRI)作用机制复杂,其过程涉及多种病理环节及信号通路。铁死亡(ferroptosis)是近年来被广泛关注的新型非凋亡性细胞死亡形式,脂质过氧化与铁超载是铁死亡的重要环节,而线粒体铁蛋白可能在铁死亡过程中起到保护作用。中医药具有多靶点、多途径的优势,以中医药干预铁死亡可能是未来治疗CIRI的新方向。本文简要综述了铁死亡的特点及发生机制,探讨中医药干预细胞铁死亡的研究现状,为进一步提升缺血性脑卒中的中医疗效提供参考。Ischemic stroke is a cerebrovascular disease caused by a regional disruption of cerebral blood flow to the brain.Although rapid and effective regeneration of the ischemic brain tissue is crucial to the treatment of ischemic stroke,there exists a risk of reperfusion injury during regeneration.The underlying mechanism of cerebral ischemia-reperfusion injury(CIRI)is complex,involving multiple pathological processes and signaling pathways.Ferroptosis is a new form of non-apoptotic cell death that has aroused extensive concern in recent years,during which process lipid peroxidation and iron overload play crucial roles while mitochondrial ferritin may be protective.Multi-target and multi-pathway as the advantages,traditional Chinese medicine(TCM)may be a new direction targeted at ferroptosis for future treatment of CIRI.This article reviews the characteristics and pathogenesis of ferroptosis and investigates the current status of TCM interventions in ferroptosis,providing a reference for further enhancing the efficacy of TCM in the treatment of ischemic stroke.

关 键 词：铁死亡 脑缺血再灌注 线粒体铁蛋白 中医药 

分 类 号：R241[医药卫生—中医诊断学]