子宫内膜异位症中雌、孕激素及其受体基因甲基化的研究进展  

Study on Methylation of Estrogen and Progesterone and Their Receptor Genes in Endometriosis

作　　者：王湘炼 朱姝 徐炜 王秀丽(审校) WANG Xiang-lian;ZHU Shu;XU Wei;WANG Xiu-li(The First Clinical Medical College of Nanjing Medical University,Nanjing 210029,China;Department of Gynecology,The First Affiliated Hospital of Nanjing Medical University,Jiangsu Province Hospital,Nanjing 210029,China)

机构地区：[1]南京医科大学第一临床医学院,210029 [2]南京医科大学第一附属医院、江苏省人民医院妇科

出　　处：《国际妇产科学杂志》2023年第2期165-169,共5页Journal of International Obstetrics and Gynecology

基　　金：江苏省卫健委科研课题(H2018017);江苏省妇幼健康重点人才课题(FRC201709)。

摘　　要：子宫内膜异位症(endometriosis,EMs)是育龄期女性的常见病及多发病,主要临床表现是痛经和不孕,复发率较高,并有潜在的恶变风险。EMs是雌激素依赖性疾病,具有孕酮抵抗特性,病灶局部雌、孕激素的合成及与受体的相互作用在EMs的发生和进展中起着十分重要的作用。局部高雌激素环境有利于异位内膜细胞的增殖、迁移、黏附和侵袭,促进EMs的发展甚至恶变;孕酮抵抗可影响子宫内膜容受性,与EMs相关性不孕密切相关。近年研究发现,DNA甲基化在EMs在位内膜和异位病灶雌、孕激素的合成及其受体表达过程中发挥重要的调控作用。了解雌、孕激素及其受体基因甲基化在EMs发生及发展、EMs相关性不孕和EMs恶变中的作用,可为EMs的诊断和药物靶向治疗研究提供依据。Endometriosis(EMs)is a common and frequent disease in women of reproductive age.The main clinical manifestations are dysmenorrhea and infertility,and there is a high recurrence rate and a potential risk of malignant transformation.EMs is an estrogen-dependent disease,with progesterone-resistant properties.The local synthesis of estrogen and progesterone in the ectopic lesions and the interactions with the receptors play an essential role in the development and progression of EMs.The local high estrogen environment favors the proliferation,migration,adhesion and invasion of ectopic endometrial cells,promoting the development of EMs and even malignancy.Progesterone resistance can affect endometrium tolerance and is closely associated with endometriosis-associated infertility.Recent studies have identified DNA methylation plays an important regulatory process in the synthesis of estrogen and progesterone and the expression of their receptors in eutopic endometrium and ectopic lesions of EMs.Understanding the role of gene methylation related to estrogen and progesterone and their receptors in the development of EMs,endometriosis-associated infertility and endometriosis-associated malignancy can provide a basis for diagnosis and drug-targeted therapy studies for EMs.

关 键 词：子宫内膜异位症 DNA甲基化 雌激素类 孕激素类 受体 雌激素 受体 孕酮 

分 类 号：R711.71[医药卫生—妇产科学]