2022年不明原因儿童严重急性肝炎暴发:可能发病机制的分析  

Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism

作　　者：邓国宏 石拓 DENG Guohong;SHI Tuo(Department of Infectious Diseases,First Affiliated Hospital,Army Medical University(Third Military Medical University),Chongqing,400038,China)

机构地区：[1]陆军军医大学(第三军医大学)第一附属医院感染病科,全军感染病研究所,重庆400038

出　　处：《陆军军医大学学报》2023年第5期373-379,共7页Journal of Army Medical University

基　　金：陆军军医大学预研项目(2018XYY10);军队双重学科建设项目(SZJYCX001)。

摘　　要：截至2022年11月,欧洲地区共22个国家累计报道不明原因儿童严重急性肝炎病例572例。在病例中最常检出的病原体为人腺病毒和新型冠状病毒。研究者们针对这两种病原体提出了可能引起发病的病因假说,但具体病因和致病机制仍尚未明确。本文从病原学及免疫病理的角度对可能引起此次肝炎疫情的致病机制进行了分析,为调查致病机制提供思路。As of November 2022,22 countries in Europe have reported 572 cases of severe acute hepatitis in children with unknown causes.The most common pathogens tested are human adenovirus and SARS-CoV-2.Therefore,the researchers have proposed hypotheses about the possible etiological hypothesis of these 2 pathogens,but the existing test results cannot clarify the specific etiology and pathogenic mechanism yet.In this article,we aims to analyze the plausible pathogenic mechanism from the perspective of etiology and immunopathology in order to provide ideas for investigating the pathogenic mechanism.

关 键 词：儿童 不明原因 严重急性肝炎 致病机制 腺病毒 组织嗜性 超抗原 遗传易感性 

分 类 号：R519.9[医药卫生—内科学] R725.126[医药卫生—临床医学]