Phase-change composite filled natural nanotubes in hydrogel promote wound healing under photothermally triggered drug release  

作　　者：Jing-Jing Ye Long-Fei Li Rui-Nan Hao Min Gong Tong Wang Jian Song Qing-Han Meng Na-Na Zhao Fu-Jian Xu Yuri Lvov Li-Qun Zhang Jia-Jia Xue 

机构地区：[1]Beijing Laboratory of Biomedical Materials,State Key Laboratory of Organic-Inorganic Composites,Beijing University of Chemical Technology,Beijing,100029,PR China [2]College of Materials Science and Engineering,Beijing University of Chemical Technology,Beijing,100029,PR China [3]Beijing Laboratory of Biomedical Materials,Beijing University of Chemical Technology,Beijing,100029,PR China [4]Institute for Micromanufacturing and Biomedical Engineering Program,Louisiana Tech University,Ruston,LA,71272,USA

出　　处：《Bioactive Materials》2023年第3期284-298,共15页生物活性材料（英文）

基　　金：National Natural Science Foundation of China(Grant No.82002049 and 52073014,to J.X.);Key Program of Beijing Natural Science Foundation(Z200025);Fundamental Research Funds for the Central Universities(buctrc202020);YL thanks support by T.Pipes Nano Microsystem Endowment,Louisiana Tech University,USA.

摘　　要：It is of great importance to treat a bacterial-infected wound by a smart dressing capable of delivering antibiotics in a smart manner without causing drug resistance.The construction of smart release nanocontainers responsive to near-infrared(NIR)laser irradiation in an on-demand and stepwise way is a promising strategy for avoiding the emergence of multidrug-resistant bacteria.Here,we develop a hydrogel composite made of alginate and nanotubes with an efficient NIR-triggered release of rifampicin and outstanding antibacterial ability.This composite hydrogel is prepared through co-encapsulating antibacterial drug(rifampicin),NIR-absorbing dye(indocyanine green),and phase-change materials(a eutectic mixture of fatty acids)into halloysite nanotubes,followed by incorporation into alginate hydrogels,allowing the in-situ gelation at room temperature and maintaining the integrity of drug-loaded nanotubes.Among them,the eutectic mixture with a melting point of 39℃ serves as the biocompatible phase-change material to facilitate the NIR-triggered drug release.The resultant phase-change material gated-nanotubes exhibit a prominent photothermal efficiency with multistep drug release under laser irradiation.In an in vitro assay,composite hydrogel provides good antibacterial potency against Staphylococcus aureus,one of the most prevalent microorganisms of dangerous gas gangrene.A bacterial-infected rat full-thickness wound model demonstrates that the NIR-responsive composite hydrogel inhibits the bacteria colonization and suppresses the inflammatory response caused by bacteria,promoting angiogenesis and collagen deposition to accelerate wound regeneration.The NIR-responsive composite hydrogel has a great po-tential as an antibacterial wound dressing functionalized with controlled multistep treatment of the infected sites.

关 键 词：ANTI-BACTERIA Clay nanotubes Alginate hydrogel Phase-change material NIR-Triggered drug release Infected wound healing 

分 类 号：TB33[一般工业技术—材料科学与工程] TQ427.26[化学工程]