负压吸引与外用睾酮霜治疗学龄期肥胖儿单纯性小阴茎的疗效分析  

Analysis of the efficacy of negative pressure suction and topical testosterone cream in the treatment of simple micropenis in school-aged obese children

作　　者：安自豪 宋翠萍[1] 张海洋[1] 饶旺[1] 贾茹 刘晖 苏丹[1] 文建国 AN Zihao;SONG Cuiping;ZHANG Haiyang;RAO Wang;JIA Ru;LIU Hui;SU Dan;WEN Jianguo(Department of Pediatric Surgery,First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院小儿外科,河南新乡453100

出　　处：《现代泌尿外科杂志》2023年第4期323-328,共6页Journal of Modern Urology

基　　金：新乡市科技攻关项目(No.CXGG17006)。

摘　　要：目的探讨负压吸引和外用睾酮霜治疗学龄期肥胖儿单纯性小阴茎的治疗效果及其对血脂和血清性激素的影响。方法收集2020年11月—2022年7月新乡医学院第一附属医院门诊就诊且完成治疗及随访的79例7~14(10.50±1.62)岁符合标准的小阴茎肥胖患儿。根据治疗方法使用区组随机方法纳入负压吸引组及外用睾酮霜组。其中负压吸引组39例,负压吸引治疗,30 min/次,1次/d,30 d为1个疗程,共1个疗程。外用睾酮霜组40例,阴茎阴囊局部涂抹睾酮霜,2次/d,30 d为1个疗程,共1个疗程。分别比较治疗前后两组患儿的龟头横径、纵径、阴茎松弛、牵伸长度、血清性激素及血脂水平。结果治疗30 d及随访2月时,两组患儿阴茎松弛、牵伸长度及龟头横、纵径均大于治疗前,组内在治疗前后差异有统计学意义(P<0.01)。外用睾酮霜组阴茎松弛、牵伸长度及龟头横、纵径的增长值均大于负压吸引组,组间差异有统计学意义(P<0.01);负压吸引组患儿血脂和性激素水平与治疗前对比,差异无统计学意义(P>0.025);外用睾酮霜组治疗30 d时血清CHOL、Apo B、Apo A1、HDL、LDL、SBG、E2、TES与治疗前对比,差异有统计学意义(P<0.025),治疗后随访2月时检测Apo A1、HDL、TES、DHS与治疗前对比,差异有统计学意义(P<0.025)。结论外用睾酮霜和负压吸引治疗学龄期肥胖儿小阴茎均有显著疗效,外用睾酮霜有一定的副作用和回缩现象。负压吸引治疗方法操作简便、安全、无副作用和回缩现象,可以推广用于肥胖儿小阴茎的治疗。Objective To investigate the efficacy of negative pressure suction and topical testosterone cream in the treatment of simple micropenis in school-aged obese children and the effects on blood lipids and serum sex hormones.Methods A total of 79 children aged 7 to 14(10.50±1.62)years treated and followed up during Nov.2020 and Jul.2022 were involved.The patients were randomly enrolled in the negative pressure suction group(n=39)and the topical testosterone cream group(n=40).The negative pressure suction group was treated with negative pressure suction for 30 min/time,1 time/day,for 30 d.The topical testosterone cream group was treated with topical testosterone cream applied to the scrotum of the penis 2 times/day for 30d.The transverse and longitudinal diameter of the glans,penile flaccidity,retraction length,serum sex hormones and blood lipids were measured before and after treatment.Results In both groups,penile flaccidity,retracted length and transverse and longitudinal diameter of the glans were significantly greater at 30 days of treatment and 2 months of follow-up than those before treatment(P<0.01).The increase in penile flaccidity,retraction length and transverse and longitudinal diameter of glans at 30 days of treatment and 2 months of follow-up were greater in the topical testosterone cream group than in the negative pressure suction group(P<0.01).There were no significant differences in the blood lipids and sex hormones in the negative pressure suction group before treatment and at 30 days of treatment and 2 months of follow-up(P>0.025).In the topical testosterone cream group,at 30 days of treatment,there were significant differences in serum total cholesterol(CHOL),apolipoprotein B(Apo B),apolipoprotein A1(Apo A1),high-density lipoprotein(HDL),low-density lipoprotein(LDL),sex hormone binding protein(SBG),estradiol(E2)and testosterone(TES)compared to those before treatment;at 2 months of follow-up,the differences in Apo A1,HDL,TES and DHS were still significant(P<0.025).Conclusion Both topical testostero

关 键 词：小阴茎 肥胖儿童 睾酮霜 负压吸引 学龄期 

分 类 号：R726.9[医药卫生—儿科]