炎症反应在围术期神经认知障碍中的作用研究进展  

Research progress on the effect of inflammation on perioperative neurocognitive disorders

作　　者：王志刚[1] 陈永学[1] 尹春平 王秋筠[2] WANG Zhigang;CHEN Yongxue;YIN Chunping;WANG Qiujun(Department of Anesthesiology,Handan Central Hospital,Handan 056008,China)

机构地区：[1]河北省邯郸市中心医院麻醉科,056008 [2]河北医科大学附属第三医院日间手术部

出　　处：《临床麻醉学杂志》2023年第2期189-192,共4页Journal of Clinical Anesthesiology

基　　金：国家自然科学基金(81771134)。

摘　　要：围术期神经认知障碍(PND)患者有发生严重并发症的风险,可能出现痴呆甚至死亡。目前,关于发生PND的具体机制尚不明确。越来越多的研究表明,PND患者和动物模型中出现促炎信号分子。外周炎性因子的释放、血脑屏障的破坏、中枢神经炎症反应的发生、神经元的凋亡和突触的丧失,提示炎症机制可能在PND的发生中起关键作用。本文对神经炎症反应在PND中的作用以及干预措施的研究进展作一综述,以期为基础研究及临床实践提供新的思路。Patients with perioperative neurocognitive disorders(PND)are at risk for serious complications that can lead to dementia and even death.At present,the specific mechanism of PND is not clear.More and more studies suggest that pro-inflammatory signaling molecules have been found both in patients with perioperative neurocognitive impairment and in animal models.The peripheral inflammatory,the destruction of blood-brain barrier,the occurrence of central nervous inflammation,neuronal apoptosis and synaptic loss suggest that inflammatory mechanisms may play a key role in the pathogenesis of PND.This review briefly describes the research progress of neuroinflammation and perioperative neurocognitive disorders,and provides new ideas for basic research and clinical practice.

关 键 词：神经炎症反应 围术期神经认知障碍 小胶质细胞 

分 类 号：R614[医药卫生—麻醉学]