不同麻醉药物抗抑郁作用及其机制的研究进展  

Research progress on antidepressant effects and mechanism of different anesthetics

作　　者：苏敬允 崔艺峰[3] 李馨[1] 刘伟[2] 安仙泉[2] 崔然吉 李炳锦 SU Jingyun;CUI Yifeng;LI Xin;LIU Wei;AN Xianquan;CUI Ranji;LI Bingjin(Medical Research Center,the Second Hospital of Jilin University,Changchun 130000,China)

机构地区：[1]吉林大学第二医院医学研究中心,长春市130000 [2]吉林大学第二医院麻醉科,长春市130000 [3]延边妇幼保健院儿科

出　　处：《临床麻醉学杂志》2023年第3期308-312,共5页Journal of Clinical Anesthesiology

基　　金：长春市科技局重点研发计划(21ZGY16)。

摘　　要：抑郁症是一种以持续的心境低落为显著特征的精神疾病。抑郁症的主要治疗方式为药物疗法,严重的情况下用电休克疗法和深度脑刺激等。然而,目前使用的抗抑郁药物有起效慢、有效性差和不良反应多等缺点。电休克疗法可能会产生记忆缺失或认知损伤,而深度脑刺激需要进行脑部手术。因此,亟需发现新的抗抑郁药物。麻醉药物因起效迅速、不良反应少等特点而成为抑郁症研究的新焦点。本文将不同麻醉药物的抗抑郁作用及其机制的最新进展进行了归纳总结,为临床提供参考。Depression is a mental disease characterized by persistent low mood.Drug therapy is the main treatment of depression,electroconvulsive therapy and deep brain stimulation are for severe cases.However,current antidepressants have the disadvantages of slow onset of action,poor efficiency and serious adverse reaction.Electroconvulsive therapy could cause memory deficits or cognitive impairment,while deep brain stimulation requires brain surgery.Therefore,there is an urgent need to discover new antidepressant drugs.Anesthetics have become a new focus on depression research because of rapid onset of action with little adverse reaction.This review summarizes the latest progress on antidepressant effects and mechanism of different anesthetics,so as to provide reference for clinic.

关 键 词：麻醉药物 抑郁症 机制 研究进展 药物疗法 

分 类 号：R614[医药卫生—麻醉学]