便秘协定方联合小麦纤维素治疗老年功能性便秘气虚证临床研究  

Clinical Study on Prescription for Constipation Combined with Wheat Cellulose for Senile Functional Constipation with Qi Deficiency Syndrome

作　　者：张仁丰 姜肖君 沈娟惠 钱新洪 姜建平 ZHANG Renfeng;JIANG Xiaojun;SHEN Juanhui;QIAN Xinhong;JIANG Jianping

机构地区：[1]浙江省荣军医院老年科,浙江嘉兴314000

出　　处：《新中医》2023年第6期64-68,共5页New Chinese Medicine

摘　　要：目的:观察便秘协定方联合小麦纤维素治疗老年功能性便秘气虚证的临床疗效。方法:将94例老年功能性便秘气虚证患者按随机数字表法分为对照组和观察组,每组47例。对照组予以小麦纤维素治疗,观察组在对照组基础上予以便秘协定方治疗,2组均治疗2周。比较2组临床疗效、不良反应发生率,以及治疗前后Cleveland便秘评分量表(CCS)、便秘患者生活质量量表(PAC-QOL)、 Bristol粪便性状评估量表(BSFS)评分与血清胃动素(MTL)、胃泌素(GAS)水平。结果:治疗后,观察组临床疗效总有效率95.74%,高于对照组82.98%(P<0.05)。治疗后,2组CCS、PAC-QOL评分均较治疗前降低(P<0.05),BSFS评分均较治疗前升高(P<0.05);观察组CCS、PAC-QOL评分均低于对照组(P<0.05),BSFS评分高于对照组(P<0.05)。治疗后,2组血清MTL、GAS水平均较治疗前升高(P<0.05),观察组血清MTL、GAS水平均高于对照组(P<0.05)。治疗期间,观察组不良反应发生率8.51%,与对照组4.26%比较,差异无统计学意义(P>0.05)。结论:便秘协定方联合小麦纤维素治疗老年功能性便秘气虚证的疗效优于单独使用小麦纤维素治疗,能显著改善患者的临床症状及生活质量,安全性良好。Objective: To observe the clinical effect of prescription for constipation combined with wheat cellulose for senile functional constipation with qi deficiency syndrome. Methods:A total of 94 cases of senile patients with functional constipation with qi deficiency syndrome were divided into the control group and the observation group according to the random number table method, with 47 cases in each group. The control group was treated with wheat cellulose, and the observation group was additionally treated with prescription for constipation based on the treatment of the control group. Both groups were treated for 2 weeks. The scores of Cleveland Constipation Scale(CCS),Patient Assessment of Constipation Quality of Life(PAC-QOL) and Bristol Stool Form Scale(BSFS),and the levels of motilin(MTL) and gastrin(GAS) in serum before and after treatment as well as the clinical effects and the incidence of adverse reactions were compared between the two groups. Results:After treatment,the total effective rate was95.74% in the observation group, higher than that of 82.98% in the control group(P<0.05). After treatment, the scores of CCS and PAC-QOL in the two groups were decreased when compared with those before treatment(P<0.05), and BSFS scores were increased when compared with those before treatment(P<0.05);the scores of CCS and PAC-QOL in the observation group were lower than those in the control group(P<0.05), and BSFS score was higher than that in the control group(P<0.05). After treatment,the levels of MTL and GAS in serum in the two groups were increased when compared with those before treatment(P<0.05),and the levels of MTL and GAS in serum in the observation group were higher than those in the control group(P<0.05). During the treatment,the incidence of adverse reactions was 8.51% in the observation group and 4.26% in the control group,there being no significant difference(P>0.05). Conclusion: Prescription for constipation combined with wheat cellulose for senile functional constipation with qi deficiency syndrome

关 键 词：功能性便秘 老年人 气虚证 便秘协定方 小麦纤维素 生活质量 胃动素 胃泌素 

分 类 号：R256.35[医药卫生—中医内科学]